Special Issue "Genetics and Epigenetics of Kidney Diseases"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: 31 March 2023 | Viewed by 554

Special Issue Editors

Dr. Andreea Andronesi
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Guest Editor
Lecturer, Nephrology Department, Fundeni Clinical Institute, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Interests: onco-nephrology; kidney involvement in hematopoietic stem cell transplantation; tuberous sclerosis complex and other rare genetic kidney diseases; monoclonal gammopathy of renal significance; cardiovascular disease in chronic kidney disease
Prof. Dr. Liliana Garneata
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Co-Guest Editor
Associate Professor, Department of Internal Medicine and Nephrology, “Dr Carol Davila” Teaching Hospital of Nephrology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Interests: epidemiology of chronic kidney disease; nutrition and metabolism in kidney diseases; anemia in chronic kidney disease; oral health impairment in chronic kidney disease; diabetic kidney disease; Fabry disease and other rare inherited kidney disorders

Special Issue Information

Dear Colleagues,

Kidney diseases are a major health problem with increasing incidence, with serious impacts on patients’ co-morbidities (mainly cardiovascular), and on patients’ quality of life and survival, but also with a huge economic impact for caregivers. Both genomic and environmental factors contribute to the development of kidney diseases. Besides monogenic inherited diseases, there are some genetic variations (e.g., APOL1 genes) that are linked to increased risk of developing kidney diseases (e.g., diabetic kidney disease, HIV-associated nephropathy, hypertensive nephropathy), especially in certain populations. Moreover, social and environmental factors play a major role in gene expression and risk of kidney diseases. A deeper understanding of all these factors and of the complex interaction between them may contribute to better patient management and outcome.

The aim of this Special Issue is to bring together international experts to provide a comprehensive overview about this important and dynamic research field. Therefore, we invite you to participate by contributing either an original research article or a review focused on some aspects of this complex topic. Research areas may include (but are not limited to) genetics and epigenetics involved in the progression of chronic kidney disease, kidney stones, kidney malignancies, progression from acute to chronic kidney disease, development and progression of common causes of chronic kidney disease (e.g., diabetic kidney disease, polycystic kidney disease, vasculitis), but also in some rare genetic diseases such as atypical hemolytic-uremic syndrome and Fabry disease.

Dr. Andreea Andronesi
Prof. Dr. Liliana Garneata
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • kidney cancer
  • kidney stones
  • risk factors
  • genomic
  • inheritance, hereditary kidney diseases

Published Papers (1 paper)

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Research

Article
Chronic Kidney Disease—An Underestimated Risk Factor for Antimicrobial Resistance in Patients with Urinary Tract Infections
Biomedicines 2022, 10(10), 2368; https://doi.org/10.3390/biomedicines10102368 - 22 Sep 2022
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Abstract
(1) Background: Chronic kidney disease (CKD), as well as antimicrobial resistance (AMR) represent major global health problems, with important social and economic implications. It was reported that CKD is a risk factor for antimicrobial resistance, but evidence is scarce. In addition, CKD is [...] Read more.
(1) Background: Chronic kidney disease (CKD), as well as antimicrobial resistance (AMR) represent major global health problems, with important social and economic implications. It was reported that CKD is a risk factor for antimicrobial resistance, but evidence is scarce. In addition, CKD is recognized to be a risk factor for complicated urinary tract infections (UTIs). (2) Methods: We conducted an observational study on 564 adult in-hospital patients diagnosed with urinary tract infections. The aim of the study was to identify the risk factors for AMR, as well as multiple drug resistance (MDR) and the implicated resistance patterns. (3) Results: The mean age was 68.63 ± 17.2 years. The most frequently isolated uropathogens were Escherichia coli strains (68.3%) followed by Klebsiella species (spp. (11.2%). In 307 cases (54.4%)), the UTIs were determined by antibiotic-resistant bacteria (ARBs) and 169 cases (30%) were UTIs with MDR strains. Increased age (≥65) OR 2.156 (95% CI: 1.404–3.311), upper urinary tract obstruction OR 1.666 (1.083–2.564), indwelling urinary catheters OR 6.066 (3.919–9.390), chronic kidney disease OR 2.696 (1.832–3.969), chronic hemodialysis OR 4.955 (1.828–13.435) and active malignancies OR 1.962 (1.087–3.540) were independent risk factors for MDR UTIs. In a multivariate logistic regression model, only indwelling urinary catheters (OR 5.388, 95% CI: 3.294–8.814, p < 0.001), CKD (OR 1.779, 95% CI: 1.153–2.745, p = 0.009) and chronic hemodialysis (OR 4.068, 95% 1.413–11.715, p = 0.009) were risk factors for UTIs caused by MDR uropathogens. (4) Conclusions: CKD is an important risk factor for overall antimicrobial resistance, but also for multiple-drug resistance. Full article
(This article belongs to the Special Issue Genetics and Epigenetics of Kidney Diseases)
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