Activation and Regulation of NLRP3 Inflammasome
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 37
Special Issue Editor
Interests: inflammasome biology; innate immunity; inflammatory diseases; drug discovery; molecular pharmacology; cell signaling; pyroptosis; autophagy; metabolic regulation; therapeutic targeting
Special Issue Information
Dear Colleagues,
The NLRP3 inflammasome represents one of the most extensively studied innate immune complexes and plays a crucial role in the host defense against pathogens and cellular damage. However, dysregulation of NLRP3 inflammasome activation contributes to the pathogenesis of numerous inflammatory, metabolic, and neurodegenerative disorders. This Special Issue aims to compile cutting-edge research and comprehensive reviews focusing on the molecular mechanisms governing NLRP3 inflammasome activation, regulation, and its implications in health and disease.
We welcome original research articles and reviews that explore various aspects of NLRP3 inflammasome biology, including but not limited to structural insights into assembly and activation; novel regulatory mechanisms involving post-translational modifications; crosstalk with other cellular pathways such as autophagy, mitochondrial dynamics, and metabolic processes; roles in specific disease contexts; and innovative therapeutic strategies targeting the NLRP3 inflammasome. Emerging technologies for studying inflammasome dynamics and the development of selective NLRP3 inhibitors are also of particular interest.
By gathering diverse perspectives and recent advances in this rapidly evolving field, this Special Issue seeks to enhance our understanding of NLRP3 inflammasome biology and accelerate the development of targeted therapeutics for inflammasome-driven diseases.
Dr. Wei Guo
Guest Editor
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Keywords
- NLRP3 inflammasome
- innate immunity
- inflammation
- pyroptosis
- caspase-1
- IL-1β
- IL-18
- DAMPs
- PAMPs
- inflammasome inhibitors
- post-translational modifications
- chronic inflammatory diseases
- metabolic disorders
- neurodegenerative diseases
- therapeutic targeting
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