Beyond BMI: Multidimensional Obesity Phenotypes, Biological Ageing, and Disease Burden
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 96
Editor
Interests: epidemiology; obesity phenotypes; body composition; biological ageing; epigenetic clocks; metabolic diseases; fatty liver disease; multimorbidity; functional ageing; precision prevention
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity-related risk is increasingly recognized as a multidimensional process that cannot be fully captured by body mass index alone. Individuals with similar BMI may differ substantially in visceral adiposity, ectopic fat deposition, skeletal-muscle reserve, metabolic health, inflammatory burden, and biological ageing status, leading to heterogeneous risks of diabetes, cardiovascular disease, fatty liver disease, cancer, frailty, disability, and premature mortality. This Special Issue aims to bring together clinical, imaging, omics, and artificial intelligence studies that refine obesity assessment and improve disease-risk stratification beyond conventional anthropometry. We welcome original research, brief reports, reviews, and translational perspectives that evaluate novel adiposity indices, body composition measures, metabolic phenotypes, imaging-derived fat metrics, epigenetic and metabolomic biomarkers, and machine-learning models for obesity phenotyping. Studies may address hidden high-risk phenotypes, including metabolically unhealthy normal weight, normal-weight obesity, sarcopenic obesity, and visceral or ectopic adiposity, as well as their implications for prevention, clinical decision-making, and healthy ageing. By integrating mechanistic, biomarker, and population-level evidence, this Special Issue seeks to support more precise, actionable, and equitable approaches to obesity-related disease prevention and management.
Dr. Xiangwei Li
Guest Editor
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Keywords
- obesity phenotypes
- visceral adiposity
- body composition
- sarcopenic obesity
- metabolic health
- biological ageing
- epigenetic biomarkers
- fatty liver disease
- cardiometabolic risk
- precision prevention
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