Role of Oxidative Stress, Antioxidants, and Gut Microbiota in Obesity and Metabolic Disorders
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Interests: obesity; metabolic diseases; antioxidants; cancer; gut microbiota; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity and metabolic diseases, including type 2 diabetes, metabolic syndrome, and non-alcoholic fatty liver disease, represent urgent global health challenges. Extensive research has demonstrated that oxidative stress and chronic low-grade inflammation are central drivers of disease onset and progression. Antioxidants, whether derived from diet, supplements, or endogenous systems, have been shown to attenuate reactive oxygen species (ROS), improve insulin sensitivity, and promote metabolic homeostasis.
Emerging evidence also emphasizes the critical role of gut dysbiosis in linking oxidative stress to metabolic dysfunction. Modulation of gut microbiota composition and function may, therefore, represent an innovative therapeutic strategy, complementing antioxidant-based approaches. In addition, mechanistic studies of mitochondrial dysfunction, lipid peroxidation, adipokine regulation, and glucose homeostasis continue to shed light on novel intervention pathways.
This Special Issue invites original research articles, reviews, and perspectives that address the role of antioxidants in treating obesity and metabolic diseases. We particularly encourage submissions that explore biological mechanisms, gut microbiota interactions, and translational clinical outcomes. By integrating multidisciplinary insights, this Special Issue aims to advance scientific understanding and foster the development of innovative strategies to alleviate the global burden of metabolic disease
Dr. Lunawati Bennett
Guest Editor
Manuscript Submission Information
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Keywords
- obesity
- metabolic diseases
- antioxidants
- gut microbiota
- inflammation
- reactive oxygen species
- cardiovascular diseases
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