New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 21
Special Issue Editor
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) plays a pivotal role in shaping cancer initiation, progression, therapeutic resistance, and patient outcomes. It consists of immune and stromal cells, an extracellular matrix, soluble mediators, and signaling pathways that dynamically interact with tumor cells. Recent advances in single-cell sequencing, spatial transcriptomics, and multi-omics profiling have uncovered the remarkable heterogeneity and adaptability of the TME, opening new avenues for biomarker discovery and therapeutic intervention.
This Special Issue, titled “New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies”, seeks to highlight cutting-edge research that enhances our understanding of TME biology and its translational implications. We welcome original research, reviews, and perspectives addressing mechanisms of immune evasion, tumor–immune crosstalk, metabolic and epigenetic regulation, stromal remodeling, and therapy-induced TME alterations. Particular attention will be given to studies investigating pharmacological interventions, including the impact of conventional drugs, natural compounds on the TME, and tumor progression. Contributions that integrate multi-omics technologies, propose TME-based prognostic models, or explore novel immunotherapeutic and combinatorial strategies are especially encouraged. By fostering interdisciplinary discussion, this Special Issue aims to advance precision oncology and accelerate the translation of TME research into innovative therapeutic opportunities.
Dr. Denggang Fu
Guest Editor
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Keywords
- tumor microenvironment (TME)
- immune evasion
- tumor–immune interaction
- stromal remodeling
- cancer immunotherapy
- metabolic reprogramming
- epigenetic regulation
- multi-omics and spatial analysis
- anticancer drug development
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