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Biomedicines
Special Issues
Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches
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Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 993

Special Issue Editors

Prof. Dr. Antonio Biondi

E-Mail Website
Guest Editor
Department of General Surgery and Surgical—Medical Specialties, University of Catania, Catania, Italy
Interests: colorectal cancer; general surgery; screening; biomarkers; quality of life; liquid biopsy; microbiota
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Vacante

E-Mail Website
Guest Editor
Unit of Internal Medicine Critical Area—ARNAS Garibaldi, Catania, Italy
Interests: colorectal cancer; elderly care; nutrition; quality of life; liquid biopsy; cancer biomarkers; microbiota
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Colorectal cancer currently represents an increasing medical and economic burden worldwide. This Special Issue will focus on the pathophysiology of colorectal cancer, with a special  interest in new diagnostic and therapeutic approaches. We invite authors to submit original research and review articles on potential topics that include biomarkers, diagnosis and therapy of colorectal cancer, and recent advances in colorectal cancer management (including combinations of multiple treatment options such as surgery, chemotherapy and immunotherapy). The role of gut microbiota in the diagnosis and therapy of colorectal cancer will also be emphasized.

Prof. Dr. Antonio Biondi
Dr. Marco Vacante
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • biomarkers
  • chemotherapy
  • immunotherapy
  • liquid biopsy
  • endoscopy
  • surgery
  • microbiota
  • screening

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Published Papers (1 paper)

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Research

17 pages, 2579 KiB  
Article
The Effect of Fungal Nutraceutical Supplementation on Postoperative Complications, Inflammatory Factors and Fecal Microbiota in Patients Undergoing Colorectal Cancer Surgery with Curative Intent: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
by Cristina Regueiro, Astrid Irene Diez Martín, Sonia Pérez, Carlos Daviña-Núñez, Sara Zarraquiños, David Remedios, Cristina Alejandra Sánchez Gómez, Sara Alonso Lorenzo, Romina Fernández Poceiro, María Luisa de Castro Parga, Vicent Hernández Ramírez, Arturo Rodríguez-Blanco, Esteban Sinde, Catalina Fernández-de-Ana and Joaquín Cubiella
Biomedicines 2025, 13(5), 1185; https://doi.org/10.3390/biomedicines13051185 - 13 May 2025
Viewed by 264
Abstract
Background/Objectives: The combination of different fungal extracts could be beneficial to cancer patients due to their role in gut microbiota modulation and anti-inflammatory activity. The study aimed to evaluate whether fungal extract supplementation reduces postsurgical complications in patients with colorectal cancer undergoing curative [...] Read more.
Background/Objectives: The combination of different fungal extracts could be beneficial to cancer patients due to their role in gut microbiota modulation and anti-inflammatory activity. The study aimed to evaluate whether fungal extract supplementation reduces postsurgical complications in patients with colorectal cancer undergoing curative surgery. Methods: Patients were randomized to receive the nutraceutical Micodigest 2.0 or a placebo until surgery. Surgical complications were evaluated using the Clavien-Dindo classification. We also assessed the effect of the nutraceutical on gut microbiota composition, inflammatory response, nutritional status, and quality of life. A subanalysis based on surgery type (robotic vs. non-robotic) was performed. Results: We included 46 patients who met the inclusion criteria, with 27 randomized to the intervention group and 19 to the placebo group, receiving treatment for three (2–4) weeks. Non-robotic surgery was performed in 35 (76.1%) patients. We found non-significant differences in postoperative complications (Micodigest 2.0: 25.9%, placebo: 26.3%; p = 0.9). In non-robotic surgery, we identified a non-significant reduction in postoperative complications (Micodigest 2.0: 25.0%, placebo: 36.4%; p = 0.7), as well as a significant increase in lymphocyte levels and a reduction in the neutrophil-to-lymphocyte ratio (p = 0.02). Micodigest 2.0 supplementation was also associated with significant changes in gut microbiota composition, as indicated by a decreased relative abundance of the phyla Firmicutes (p = 0.004) and Actinobacteria (p = 0.04). Conclusions: Micodigest 2.0 supplementation was associated with non-significant reductions in postoperative complications and significant modifications in gut microbiota composition. Limitations: The trial did not reach the calculated sample size. Full article
(This article belongs to the Special Issue Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches)
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