Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Related Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: closed (31 August 2025) | Viewed by 1997
Special Issue Editors
Interests: mitochondria; cardiac health; transgenesis; neuroinflammation; cell biology
Special Issue Information
Dear Colleagues,
Mitochondrial dysfunction plays a significant role in the aging process and is associated with various age-related diseases. Understanding and addressing mitochondrial health are crucial for developing interventions that can improve quality of life and mitigate the effects of aging. Aging is characterized by a progressive decline in mitochondrial function, which is primarily caused by elevated levels of reactive oxygen species (ROS) and mitochondrial DNA mutations. These ROS induce oxidative damage to cellular components, leading to diminished respiratory chain activity and reduced ATP production. Mitochondrial fission and fusion are essential for regulating mitochondrial function, metabolism, and quality control. As we age, disruptions in these processes can hinder mitophagy. This impairment results in the build-up of defective mitochondria within cells, further escalating mitochondrial damage and impairing cellular function. Consequently, genetic mutations or declines in mitochondrial dynamics and quality control are linked to the development of various age-related disorders, including metabolic syndrome, neurodegenerative diseases, cardiovascular conditions, and cancer.
This Special Issue highlights the latest research on the role of mitochondrial dysfunction in aging and disease. We invite authors to submit original research and review articles that explore how mitochondrial abnormalities contribute to disease development and progression. We welcome submissions focused on cutting-edge mitochondrial-based therapies with potential for clinical translation, as well as approaches that address mitochondrial biogenesis, clearance, and signaling. We hope that our Special Issue will reflect current and novel insights into the role of mitochondria in aging and disease.
Dr. Pankaj Patyal
Dr. Gohar Azhar
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial dysfunction
- aging
- reactive oxygen species
- mitochondrial dynamics
- mitophagy
- mitochondrial biogenesis
- age-related disorders
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