Role of Natural Product in Cardiovascular Disease—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 585

Special Issue Editor

Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street, SE, Atlanta, GA 30303, USA
Interests: vascular biology; cardiovascular disease; metabolic diseases; evaluation of bioactive agents from natural sources
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD), generally referring to a group of disorders of the heart and vessels as well as their associated adverse conditions, has been the leading cause of morbidity and mortality worldwide. The majority of CVD is caused by physiological or metabolic risk factors that can be controlled, modified or treated, such as hyperlipidemia, blood viscosity, atherosclerosis, hypertension, obesity and diabetes. Currently, the common therapeutical medication strategies of CVD have largely depended on lipid-lowering statins, blood thinners, and beta blockers. However, some patients do not achieve ideal effects from these traditional therapeutics. Therefore, there is still an unmet medical need to seek new therapeutic modalities for CVD treatment.

Natural products have been emerged as a novel source of leading compounds for cardiovascular drug discovery, because of their broad spectrum of pharmacological and biological activities, including lipid-lowering, antioxidant, anti-inflammatory, anti-thrombotic and immunomodulatory effects. Thus, in this Special Issue, we invite full-length research and review articles associated with the biological effect of natural products in preventing/counteracting cardiovascular diseases. This special issue only includes research “with defined molecular compound”.

The proposed topics of interest include, but are not limited to:

  • Clinical or preclinical studies investigating natural products in the treatment of CVD;
  • The role of natural products in preventing/counteracting vascular remodeling;
  • The role of natural products in preventing/counteracting cardiac metabolic dysfunction;
  • The use of natural products as leading compounds in drug discovery for the treatment of CVD;
  • Pathogenesis and novel risk factors of CVD;
  • Potential therapeutic targets of CVD.

Dr. Jian Li
Guest Editor

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Keywords

  • nature products
  • phytochemicals
  • biological and pharmacological activity
  • cardiovascular disease (CVD) pathogenesis of CVD
  • risk factors of CVD
  • metabolic symptom
  • clinical or preclinical studies

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Published Papers (1 paper)

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Research

22 pages, 7308 KiB  
Article
Inulin Diet Alleviates Abdominal Aortic Aneurysm by Increasing Akkermansia and Improving Intestinal Barrier
by Shuang Guo, Fen Yang, Jiyu Zhang, Yuhan Liao, Ni Xia, Tingting Tang, Chaolong Wang, Qing K. Wang, Chen Chen, Desheng Hu, Zhilei Shan and Xiang Cheng
Biomedicines 2025, 13(4), 920; https://doi.org/10.3390/biomedicines13040920 - 9 Apr 2025
Viewed by 307
Abstract
Background/Objectives: Previous studies have shown varying efficacy of high-fiber diets containing different ingredients in abdominal aortic aneurysms (AAAs). This study aimed to identify which high-fiber diet protects against AAA in mice and elucidate the underlying mechanisms. Methods: This study compared inulin, [...] Read more.
Background/Objectives: Previous studies have shown varying efficacy of high-fiber diets containing different ingredients in abdominal aortic aneurysms (AAAs). This study aimed to identify which high-fiber diet protects against AAA in mice and elucidate the underlying mechanisms. Methods: This study compared inulin, cellulose, and chow diets in terms of their impact on aneurysm enlargement, elastin degradation, matrix metalloproteinase 2 and 9 expressions, CD3+ T cell and CD68+ macrophage infiltration, and macrophage differentiation. It also examined gut microbiota composition, focusing on Akkermansia, and evaluated intestinal barrier function and systemic inflammatory response. Results: The inulin diet, but not the cellulose diet, compared with the chow diet, reduced aneurysm enlargement, elastin degradation, matrix metalloproteinase 2 and 9 expressions, CD3+ T cell and CD68+ macrophage infiltration, and skewed macrophage towards M2 differentiation. The inulin diet enriched Akkermansia in both the small and large intestine. The inulin diet also enhanced the intestinal barrier by augmenting goblet cells, upregulating the gene related to the epithelial barrier and antibacterial peptides in the small intestine, and reducing circulating lipopolysaccharide and interleukin-1β levels. The inulin diet lowered the proportion of Ly6Chi monocytes and C-C chemokine receptor 2 expression on these cells in the bone marrow, reducing aneurysm infiltration. Administering Akkermansia to AAA mice decreased intestinal permeability and mitigated AAA. Conclusions: A diet rich in fermentable fiber inulin, as opposed to cellulose, alleviates AAA in mice. This beneficial effect is attributed to the enhanced presence of Akkermansia bacteria and improvement of the intestinal barrier. Full article
(This article belongs to the Special Issue Role of Natural Product in Cardiovascular Disease—2nd Edition)
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