Targeting Genomic Instability in Cancer
A Special Issue of Biomedicines (ISSN 2227-9059) belonging to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 May 2027 | Viewed by 36
Editors
Interests: cancer biology; cell signaling; DNA damage response; DNA replication stress; post-translational modification
Special Issue Information
Dear Colleagues,
Genomic instability is a hallmark of cancer that promotes tumor initiation, evolution, and therapeutic resistance. At the same time, the accumulation of genomic alterations and replication-associated stress creates vulnerabilities that can be exploited therapeutically. Cancer cells must maintain sufficient genome integrity to survive and proliferate, creating a critical balance between genomic instability and dependence on DNA damage response (DDR) and repair mechanisms.
Radiotherapy and genotoxic therapies exploit these vulnerabilities by inducing DNA damage and replication stress that can ultimately compromise cancer cell survival. However, tumor cells can activate or reprogram genomic surveillance mechanisms to tolerate therapeutic stress and promote treatment resistance. These mechanisms encompass DNA damage and cell-cycle checkpoints, DNA repair pathways, replication stress responses, and other processes that preserve genome integrity. Understanding how cancer cells utilize these networks, and how they can be therapeutically disrupted, may reveal new strategies to enhance treatment response and overcome resistance.
This Special Issue, “Targeting genomic instability in Cancer,” aims to highlight advances in our understanding of genomic instability as a therapeutic vulnerability in cancer. We welcome original research articles and reviews addressing the mechanisms and therapeutic implications of DNA damage and repair, DNA damage response signaling, replication stress, cell-cycle checkpoints, genomic instability, resistance to radiotherapy and genotoxic therapies, and emerging strategies that exploit genomic instability and genome maintenance vulnerabilities to improve cancer treatment.
Dr. Haihua Feng
Dr. Veronica Castro-Aceituno
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA damage response (DDR)
- DNA replication stress
- genomic instability
- radiotherapy
- chemotherapy
- therapeutic resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
