mRNA-Based Cancer Immunotherapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4061
Special Issue Editor
Special Issue Information
Dear Colleagues,
Following the overwhelming success of mRNA-based vaccination in the COVID-19 pandemic, the focus of this technology has moved forward to alternative targets, including treatment of cancer.
The major, initial hurdles for mRNA-based vaccines, such as instability of mRNA, inefficient delivery, weak immunogenicity, and large-scale production, have been resolved for the COVID-19 indication. For cancer, however, these issues need to be readdressed but should, hopefully, not constitute a major obstacle.
In cancer indications, other challenges have to be overcome, such as selection of the tumor type, status and disease stage of patients, antigen(s) selection, packaging of the product (e.g., again using nanomaterials), route of administration, and immunological response and side effect rates. An additional important aspect that needs to be addressed is the feasibility of prophylactic administration of mRNA vaccination with the final objective of making therapeutic use no longer necessary.
All these issues will be addressed in this Special Issue of Biomedicines. Authors in the field of mRNA-based immunotherapy are cordially invited to submit original research or review articles contributing to this important and fast-progressing area of biomedicine.
Dr. Werner Krause
Guest Editor
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Keywords
- mRNA vaccination
- cancer
- antigen selection
- nanomaterials
- clinical trials
- large-scale production
- prophylactic and therapeutic use
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