Special Issue "Novel Antibacterial, Antibiofilm and Anti-virulence Candidates"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 2387
Interests: bacterial virulence; bacterial resistance; bacteria as a vehicle for vaccination; repurposing of drugs; anti-virulence agents
2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Interests: nanoparticles; anticancer; cancer immunotherapy; drug delivery
Special Issues, Collections and Topics in MDPI journals
2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Interests: medicinal chemistry; development of new drugs; anticancer; antivirals; antibacterial
The growing microbial resistance to antibiotics is an increasingly challenging issue that global health faces. The dwindling discovery of new antibiotics worsens the situation and mandates new approaches and strategies to conquer microbial resistance. Bacteria recruit diverse virulence factors and employ several systems to control the regulation of these virulence arsenals. Among the most resistant microbial phenotypes, bacterial biofilms constitute a huge obstacle against efficient antibiotic treatments. Targeting bacterial virulence and diminishing biofilms greatly attenuates bacteria and eases their eradication through antibiotics. Targeting virulence can be achieved by targeting virulence-controlling systems. Among the most involved virulence-controlling systems, quorum sensing (QS) plays a crucial role in orchestrating the production of bacterial virulence factors and biofilms. Moreover, several approaches have been suggested to eradicate bacterial biofilms and inhibit bacterial virulence, such as the use of antimicrobial nanoparticles and antimicrobial peptides (AMPs). This issue focuses on the discovery of new antibacterial and antibiofilm candidates to serve as adjuvants to antibiotics in the treatment of aggressive infections.
Dr. Wael Hegazy
Dr. Amr S. Abu Lila
Dr. Tarek S. Ibrahim
Manuscript Submission Information
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- approaches to target bacterial virulence
- new antibacterial candidates
- anti-virulence agents
- antibiofilm agents
- quorum sensing targeting
- antibiofilm nanoparticle
- anti-virulence nanoparticles
- antimicrobial peptides (AMPs)
- evaluation of antibiotics’ adjuvants in the treatment of aggressive infections
- gram-positive and -negative biofilms
- candida biofilms