Emerging Topics in Hydrocephalus
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1770
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hydrocephalus is not a single pathology, but a group of multiple pathologies whose prevalence is unknown. The clinical repercussions are major for the patient in terms of disability, with the development of a clinical triad described by Salomon Hakim and early mortality.
Among these pathologies, some have an etiological diagnosis. These are secondary hydrocephalus (post-infectious, posthemorrhagic, etc.). However, the mechanisms of the genesis of hydrocephalus are not perfectly described.
Most chronic hydrocephalus remains idiopathic. These cases of idiopathic hydrocephalus are grouped together in a single entity often called “idiopathic normal pressure hydrocephalus”. Their pathophysiology is unknown. Therefore, the mechanisms of action of the treatment are not known, and it does not address the cause. This makes management complex in many cases. In addition, surgical treatment is often effective only for a limited time, and in many cases for about 24 months.
It seems in recent works that there is a link between the presence of biomarkers in the CSF and the secondary degradation of the operated patients. A molecular pathway to the development of chronic hydrocephalus is being considered, which would be secondary to felting of the intracranial fluid spaces. Alterations in the dynamics of the cerebrospinal fluid (CSF) have also been found at different levels of study (basal cisterns, spinal subarachnoid spaces, intraventricular). These findings may lead to the description of cerebral compliance disorders at different sites.
The aim of this Special Issue on hydrocephalus is to describe the different pathophysiological leads to help remove the term idiopathic from our language when we talk about hydrocephalus. This includes studies on the pathophysiology or the development of new and justified classifications of hydrocephalus.
Dr. Cyrille Capel
Guest Editor
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Keywords
- hydrocephalus
- CSF
- CSF biomarkers
- cerebral hydrodynamic
- cerebral hemodynamics
- aging disorders
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