Hydrodynamic and Hemodynamic Interactions in Chronic Hydrocephalus
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients
2.2. MRI Acquisition
2.3. Data Analysis
- -
- SVCSF: corresponds to the stroke volume of CSF, which oscillates through the upper cervical SAS at the level of the C2C3 intervertebral disc during one cardiac cycle. This reflects variations in intracranial CSF volume during a cardiac cycle.
- -
- SVAV: corresponds to the volume of blood, which oscillates in the cranial compartment during one cardiac cycle. This reflects variations in intracranial vascular volume during a cardiac cycle.
- -
- Hemohydrodynamic ratio: ratio between SVCSF and SVAV. SVCSF is the passive response of CSF to a pressure gradient between intracranial and spinal SAS (). SVAV is the main factor in intracranial volume variation during a cardiac cycle (). The combination of these two parameters gives the ratio of a change in volume to a change in pressure.
2.4. Statistical Analysis
2.5. Ethics
3. Results
3.1. Comparison of Hemodynamic and Hydrodynamic Parameters in Probable and Unlikely Hydrocephalus Populations
3.2. Analysis of Hemohydrodynamic Interactions in Probable and Unlikely Hydrocephalus Populations
4. Discussion
4.1. Comparison of Hemodynamics in Probable and Unlikely Hydrocephalus Populations
4.2. Comparison of Hydrodynamics in Probable and Unlikely Hydrocephalus Populations
4.3. Analysis of Hemohydrodynamic Interactions in the Two Patient Groups
4.4. Compliance in Chronic Hydrocephalus
4.5. Limits
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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CINE-PC | |
---|---|
Venc (cm/s) | 60 (blood)/5 (CSF) |
FOV (cm2) | 14 × 14 |
Resolution (mm2) | 1 × 1 |
Thickness (mm2) | 2 |
Flip Angle (degree) | 30 |
EPI-factor | NA |
SENSE | 1.5 |
TE (ms) | 6.6 |
TR (ms) | 10.9 |
Readout time (ms) | 5.3 |
Number of images | 32 |
Acquisition time (s) | 50–115 |
Number of images per cycle | 32 |
Unlikely Hydrocephalus | Probable Hydrocephalus | p-Value | |
---|---|---|---|
Age (years) | 75 ± 7 | 73 ± 8 | 0.63 |
Sex ratio (F/M) | 2/3 | 6/7 | 0.82 |
SVAV (mL/cc) | 0.82 ± 0.20 | 0.71 ± 0.17 | 0.44 |
SVCSF (mL/cc) | 0.54 ± 0.18 | 0.42 ± 0.20 | 0.13 |
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Capel, C.; Owashi, K.; Peltier, J.; Balédent, O. Hydrodynamic and Hemodynamic Interactions in Chronic Hydrocephalus. Biomedicines 2023, 11, 2931. https://doi.org/10.3390/biomedicines11112931
Capel C, Owashi K, Peltier J, Balédent O. Hydrodynamic and Hemodynamic Interactions in Chronic Hydrocephalus. Biomedicines. 2023; 11(11):2931. https://doi.org/10.3390/biomedicines11112931
Chicago/Turabian StyleCapel, Cyrille, Kimi Owashi, Johann Peltier, and Olivier Balédent. 2023. "Hydrodynamic and Hemodynamic Interactions in Chronic Hydrocephalus" Biomedicines 11, no. 11: 2931. https://doi.org/10.3390/biomedicines11112931