Pathophysiology, Risk Factors and Management in HFpEF Patients with Comorbidities

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1673

Special Issue Editors

National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou, China
Interests: heart failure; atrial fibrillation; clinical prognosis; remodeling

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Guest Editor
Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Interests: heart failure; atrial fibrillation; molecular mechanism.
Department of Cardiology, Sun Yat-Sen Memorial Hospital, Guangzhou, China
Interests: heart failure; atrial fibrillation; clinical prognosis

Special Issue Information

Dear Colleagues,

Heart failure with preserved ejection fraction (HFpEF) is a highly complex clinical syndrome, representing the most common type of heart failure. It is often characterized by a high prevalence of coexisting comorbidities, such as atrial fibrillation, diabetes mellitus, hypertension and obesity. HFpEF patients with comorbidities have higher risks of worse clinical outcomes in clinical settings. Therefore, the early identification of those HFpEF patients at a high risk of comorbidities may prompt the initiation of prevention management, and thus improve prognosis. In this research topic, we would like to create a forum for discussion on the current understanding of the pathophysiology, risk factors and management of HFpEF patients with comorbidities. We welcome submissions of original articles, reviews covering, but not limited to, the following subtopics:

  1. The current understanding of the pathophysiology (especially molecular mechanisms) of comorbidities in HFpEF.
  2. Risk factors associated with disease development, or risk models for predicting comorbidities in HFpEF.

Dr. Wengen Zhu
Dr. Jianyong Ma
Dr. Xiao Liu
Guest Editors

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Keywords

  • heart failure
  • pathophysiology
  • risk factors
  • management
  • prognosis

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Published Papers (1 paper)

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Research

10 pages, 1809 KiB  
Article
Worsening Renal Function and Adverse Outcomes in Patients with HFpEF with or without Atrial Fibrillation
by Linjuan Guo and Xiaojuan Wu
Biomedicines 2023, 11(9), 2484; https://doi.org/10.3390/biomedicines11092484 - 7 Sep 2023
Cited by 1 | Viewed by 1150
Abstract
Since worsening renal function (WRF) and atrial fibrillation (AF) often coexist in preserved ejection fraction (HFpEF), we aimed to investigate the effect of WRF on the prognosis of HFpEF patients with and without AF. The study population of this study (n = 1763) [...] Read more.
Since worsening renal function (WRF) and atrial fibrillation (AF) often coexist in preserved ejection fraction (HFpEF), we aimed to investigate the effect of WRF on the prognosis of HFpEF patients with and without AF. The study population of this study (n = 1763) was based on the subset of the Americas in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial (TOPCAT). We found that the cumulative probabilities of the primary composite outcome and cardiovascular death were significantly higher in AF patients post-WRF when compared to non-AF patients. In the time-dependent Cox proportional hazard model, WRF was significantly associated with higher risks of adverse outcomes (primary composite outcome: HR = 1.58 (95% CI, 1.19–2.11); all-cause death: HR = 1.50 (95% CI, 1.10–2.06); cardiovascular death: HR, 2.00 (95% CI, 1.34–3.00)) after adjustments for confounding factors at baseline in HFpEF patients with AF, whereas in HFpEF patients without AF, WRF was not significantly associated with any adverse outcome. p for interactions for the primary composite outcome, cardiovascular death, and AF were significant. In conclusion, these findings highlight that WRF was associated with a greater risk of the primary composite outcome, all-cause death, and cardiovascular death in HFpEF patients with AF. Full article
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