Tumor Microenvironment and Cancer Therapy (2nd Edition)

Dear Colleagues,

The tumor microenvironment has a decisive role in tumor differentiation, epigenetics, dissemination, and immune evasion. In fact, the tumor microenvironment is a highly heterogeneous milieu consisting of different cell types and many abundant molecules produced and released by tumor cells, stromal cells, and immune cells. In particular, evidence suggests that the vital components of the tumor microenvironment are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, blood and lymphatic vascular networks, and extracellular matrices. The physiological state of the tumor microenvironment is closely connected to every step of tumorigenesis. It is important to understand the role of different components of the tumor microenvironment in the treatment and prevention of tumors. Therefore, it is essential to consider the different aspects of the tumor microenvironment when designing new therapies and new treatment protocols for cancer patients.

This Special Issue aims to provide an update on cancer therapies and examine new mechanisms to understand the role of the tumor microenvironment. Indeed, evaluating the correlation between cancer and microenvironment could help to avoid failures linked to a lack of clinical benefit found over the years and improve the overall survival of oncologic patients even in the professional field.

Dr. Eva Andreuzzi
Prof. Dr. Venerando Antonio Rapisarda
Guest Editors

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