Navigating the Tumor Microenvironment: The Role of Reactive Oxygen Species in Cancer Progression and Therapy
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 466
Special Issue Editor
Interests: oxidative stress and free radical biology; microbial infections; tumor immunology; cancer biology; pancreatic; tumor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) plays a crucial role in defining the progression of different cancers. Reactive oxygen species (ROS) produced by tumor cells and tumor-infiltrated immune cells are essential in shaping the TME. The stromal components of the tumor can affect the TME and influence drug response in tumor cells. In multiple cancers, chemotherapy and radiotherapy have been shown to increase intracellular ROS, which can lead oxidative stress (OS)-induced apoptosis and cell death. Oxidative stress is defined as an imbalance between the production of ROS and their elimination by protective antioxidants. OS can cause DNA mutations and/or genomic instability. This leads to the initiation and progression of cancer. However, when discussing the role of OS in cancers, ROS act as a double‐edged sword. Although low levels of ROS can induce a proliferative effect and induce signaling pathways, high levels of ROS can cause damage to cancer tissues and cell death. Antioxidants can spare and protect normal tissues. However, existing data indicate that antioxidants may also protect tumor cells from oxidative damage induced by some chemotherapeutic agents. In this Special Issue, we will discuss recent findings relating oxidative stress and ROS to the TME in cancer and responses to chemo- and radiotherapy. In addition, we discuss how different studies may aid in identifying new targets for the development of drugs for cancer therapy.
Dr. Maher Y. Abdalla
Guest Editor
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Keywords
- tumor microenvironment
- reactive oxygen species
- oxidative stress
- antioxidants
- tumor-infiltrated immune cells
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