Advances in Biotechnology and Application of Microbial Surfactants

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biochemical Engineering".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 61

Special Issue Editors

Guest Editor
Food & Energy Security Research & Product Center, Sendai, Japan
Interests: lipids; proteins; biosurfactants; biomolecular phase behavior; microbial extraction; application of microbial surfactants; microbes cultivation
Special Issues, Collections and Topics in MDPI journals

Guest Editor
Nagoya Institute of Technology, Nagoya, Japan
Interests: lipids; proteins; membrane channels; peptides; biomembranes; monolayers (natural lipids and synthetic lipids) Brewster angle microscopy; surface pressure-molecular area isotherms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biotechnology is a rapidly evolving field that has a significant impact on various industries. The application of microbial surfactants is one of the most promising areas in this field. These biocompatible and eco-friendly compounds show great potential for applications in fields such as agriculture, healthcare and environmental remediation.

Our proposal in this Special Issue is to extract biosurfactants based on the pattern of production and modification of amphotericin B and analogues, as well as truncated polyketide intermediates produced by genetic engineering in Streptomyces nodosus. Amphotericin B and similar antibiotics also work as biosurfactants, as they have been investigated from an amphiphilic molecule viewpoint, along with acting as a powerful but toxic drug used against fungal infections and leishmaniases.  On a large scale, molecules and intermediates can be produced at a low cost by genetic modifications that have produced amphotericin B from Streptomyces nodosus. We propose improved methods for the manufacture and purification of such molecules (surfactants) with complete chemical analysis.  The new bacterial mutants will produce biological surface active agents for commercial and research purposes. Hamycin, another polyene antifungal antibiotic (also a biosurfactant) belonging to the group of heptaene polyantibiotics, is produced by Streptomyces pimprina, an actinomycete isolated from soil. The genetic modification of these bacteria has not been conducted so far, which offers an opportunity for researchers in this Special Issue. Potential oleaginous microorganisms that produce omega-3 fatty acid-based surfactants that are useful in many food and pharmaceutical industries will also be covered in this issue. Some of the microorganisms can produce up to 50% of the required lipids.

This special issue aims to introduce the latest advances in biotechnology and the application of microbial bio-surfactants, we welcome contributions from scholars in the field.

Dr. Zameer Shervani
Dr. Yasushi Yamamoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biosurfactants
  • production of biolipids biomolecular phase behavior
  • microbial extraction
  • application of microbial surfactants
  • microbes cultivation
  • bioengineering of microbes
  • genetic engineering of microbes

Published Papers

This special issue is now open for submission.
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