Bioengineered Organs for Transplantation: Unveiling the Future of Organ Replacement

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 524

Special Issue Editor


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Guest Editor
Department of Pathology, University of Illinois at Chicago, Chicago, IL 60637, USA
Interests: liver transplantation

Special Issue Information

Dear Colleagues,

The field of organ transplantation has advanced remarkably over the years, offering new hope to countless individuals suffering from end-stage organ failure. However, the severe shortage of donor organs remains a significant barrier to meeting the increasing demand. Bioengineering presents a promising solution by harnessing cutting-edge technologies in order to fabricate functional organs that can be transplanted into patients, eliminating their reliance on traditional organ sources.

This Special Issue aims to delve into the realm of bioengineered organs for transplantation, shedding light on the latest breakthroughs, innovations, and challenges shaping the future of organ replacement. By gathering original research articles, reviews, and case studies, we aim to provide a comprehensive platform to explore advances in bioengineering strategies, cellular and tissue engineering, and regenerative medicine, ultimately promoting the development of successful and safe bioengineered organs for clinical translation.

Topics of Interest:

  1. Novel bioengineering techniques for organ fabrication
  2. Cellular and molecular mechanisms of organ development and regeneration
  3. Stem cell-based approaches for organ biofabrication
  4. Biomaterial design and selection for organ engineering
  5. Bioreactor systems and 3D tissue culture technologies
  6. Immunological considerations and strategies for organ transplantation
  7. Evaluating the functionality and performance of bioengineered organs
  8. Translational aspects, including preclinical testing and regulatory challenges
  9. Ethical, social, and legal implications of bioengineered organs

Dr. Zhuolun Song
Guest Editor

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Keywords

  • bioengineered organs
  • transplantation
  • regenerative medicine
  • tissue engineering
  • organ fabrication
  • biofabrication techniques
  • cellular reprogramming
  • biomaterials
  • bioreactor systems
  • preclinical testing

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Published Papers (1 paper)

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Research

15 pages, 15638 KiB  
Article
Comparative Evaluation of Bovine- and Porcine-Deproteinized Grafts for Guided Bone Regeneration: An In Vivo Study
by Blaire V. Slavin, Vasudev Vivekanand Nayak, Marcelo Parra, Robert D. Spielman, Matteo S. Torquati, Nicholas J. Iglesias, Paulo G. Coelho and Lukasz Witek
Bioengineering 2025, 12(5), 459; https://doi.org/10.3390/bioengineering12050459 - 26 Apr 2025
Viewed by 80
Abstract
Guided bone regeneration (GBR) procedures have been indicated to enhance bone response, reliably regenerate lost tissue, and create an anatomically pleasing ridge contour for biomechanically favorable and prosthetically driven implant placement. The aim of the current study was to evaluate and compare the [...] Read more.
Guided bone regeneration (GBR) procedures have been indicated to enhance bone response, reliably regenerate lost tissue, and create an anatomically pleasing ridge contour for biomechanically favorable and prosthetically driven implant placement. The aim of the current study was to evaluate and compare the bone regenerative performance of deproteinized bovine bone (DBB) and deproteinized porcine bone (DPB) grafts in a beagle mandibular model for the purposes of GBR. Four bilateral defects of 10 mm × 10 mm were induced through the mandibular thickness in each of the 10 adult beagle dogs being studied. Two of the defects were filled with DPB, while the other two were filled with DBB, after which they were covered with collagen-based membranes to allow compartmentalized healing. Animals were euthanized after 6, 12, 24, or 48 weeks postoperatively. Bone regenerative capacity was evaluated by qualitative histological and quantitative microtomographic analyses. Microcomputed tomography data of the bone (%), graft (%), and space (%) were compared using a mixed model analysis. Qualitatively, no histomorphological differences in healing were observed between the DBB and DPB grafts at any time point. By 48 weeks, the xenografts (DBB and DPB) were observed to have osseointegrated with regenerating spongy bone and a close resemblance to native bone morphology. Quantitatively, a higher amount of bone (%) and a corresponding reduction in empty space (space (%)) were observed in defects treated by DBB and DPB grafts over time. However, no statistically significant differences in bone (%)were observed between DBB (71.04 ± 8.41 at 48 weeks) and DPB grafts (68.38 ± 10.30 at 48 weeks) (p > 0.05). GBR with DBB and DPB showed no signs of adverse immune response and led to similar trends in bone regeneration over 48 weeks of permitted healing. Full article
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