Advances in Drug Delivery in Cancer Treatment

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 610

Special Issue Editor

Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China
Interests: drug delivery; cancer therapy

Special Issue Information

Dear Colleagues,

Cancer is a complex and challenging disease that continues to be a major health concern worldwide. Recent advances in drug delivery systems have shown promise in improving the efficacy and safety of cancer treatment. The development of targeted drug delivery systems has allowed for the more precise delivery of anti-cancer drugs to tumor sites, reducing off-target effects and minimizing toxicity. Nanotechnology-based drug delivery systems, such as nanoparticles and liposomes, have enabled enhanced drug delivery across biological barriers and improved drug stability, bioavailability, and pharmacokinetics. Additionally, the use of combination therapies, including drug-loaded nanoparticles and immunotherapy, has shown synergistic effects in enhancing anti-cancer activity and overcoming drug resistance.

This Special Issue aims to highlight the latest research and developments in drug delivery for cancer treatment. It will feature original research articles, reviews, and perspectives that cover a wide range of topics, including novel drug delivery systems, targeting strategies, biomaterials, and clinical translation of drug delivery technologies. By bringing together researchers and experts in the field, this Special Issue will provide valuable insights into the current challenges and opportunities in drug delivery for cancer therapy.

Dr. Chang Yang
Guest Editor

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Keywords

  • cancer
  • drug delivery
  • nanotechnology
  • targeted therapy
  • combination therapy
  • biomaterials

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Published Papers (1 paper)

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Research

16 pages, 3793 KiB  
Article
Composites of Reduced Graphene Oxide Based on Silver Nanoparticles and Their Effect on Breast Cancer Stem Cells
by Babu Vimalanathan, Devasena Thiyagarajan, Ruby Nirmala Mary, Magesh Sachidanandam, Savarimuthu Ignacimuthu, Dhanavathy Gnanasampanthapandian, Johnson Rajasingh and Kanagaraj Palaniyandi
Bioengineering 2025, 12(5), 508; https://doi.org/10.3390/bioengineering12050508 - 11 May 2025
Viewed by 380
Abstract
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly in targeting cancer stem cells (CSCs). A range of analytical [...] Read more.
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly in targeting cancer stem cells (CSCs). A range of analytical techniques, such as X-ray diffraction (XRD), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and UV–visible absorption spectroscopy (UV–VIS), were employed to characterize graphene oxide (GO), reduced graphene oxide (rGO)–silver nanoparticles (AgNPs), and their composite structures. The GO-rGO-AgNPs exhibited potent anticancer properties as evidenced by cell culture assays, spheroid formation assay, and quantitative RT-PCR analysis. Treatment of breast cancer cells (MCF-7) with GO, rGO, and AgNPs significantly reduced cell proliferation and mammosphere formation. Furthermore, these treatments downregulated the expression of marker genes associated with CSCs in MCF-7 cells. Among the tested materials, rGO-AgNP, sodium citrate-mediated GO-AgNP, and rGO-AgNP nanocomposites demonstrated superior inhibitory effects on cell survival compared to GO alone. These findings suggest that these nanocomposites hold promise as effective and non-toxic therapeutic agents for targeting cancer cells and CSCs, thereby offering a novel approach to cancer treatment. Full article
(This article belongs to the Special Issue Advances in Drug Delivery in Cancer Treatment)
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