Advances in Drug Delivery in Cancer Treatment

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1811

Special Issue Editor

Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China
Interests: drug delivery; cancer therapy

Special Issue Information

Dear Colleagues,

Cancer is a complex and challenging disease that continues to be a major health concern worldwide. Recent advances in drug delivery systems have shown promise in improving the efficacy and safety of cancer treatment. The development of targeted drug delivery systems has allowed for the more precise delivery of anti-cancer drugs to tumor sites, reducing off-target effects and minimizing toxicity. Nanotechnology-based drug delivery systems, such as nanoparticles and liposomes, have enabled enhanced drug delivery across biological barriers and improved drug stability, bioavailability, and pharmacokinetics. Additionally, the use of combination therapies, including drug-loaded nanoparticles and immunotherapy, has shown synergistic effects in enhancing anti-cancer activity and overcoming drug resistance.

This Special Issue aims to highlight the latest research and developments in drug delivery for cancer treatment. It will feature original research articles, reviews, and perspectives that cover a wide range of topics, including novel drug delivery systems, targeting strategies, biomaterials, and clinical translation of drug delivery technologies. By bringing together researchers and experts in the field, this Special Issue will provide valuable insights into the current challenges and opportunities in drug delivery for cancer therapy.

Dr. Chang Yang
Guest Editor

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Keywords

  • cancer
  • drug delivery
  • nanotechnology
  • targeted therapy
  • combination therapy
  • biomaterials

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Published Papers (2 papers)

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Research

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16 pages, 3793 KB  
Article
Composites of Reduced Graphene Oxide Based on Silver Nanoparticles and Their Effect on Breast Cancer Stem Cells
by Babu Vimalanathan, Devasena Thiyagarajan, Ruby Nirmala Mary, Magesh Sachidanandam, Savarimuthu Ignacimuthu, Dhanavathy Gnanasampanthapandian, Johnson Rajasingh and Kanagaraj Palaniyandi
Bioengineering 2025, 12(5), 508; https://doi.org/10.3390/bioengineering12050508 - 11 May 2025
Viewed by 1471
Abstract
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly in targeting cancer stem cells (CSCs). A range of analytical [...] Read more.
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly in targeting cancer stem cells (CSCs). A range of analytical techniques, such as X-ray diffraction (XRD), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and UV–visible absorption spectroscopy (UV–VIS), were employed to characterize graphene oxide (GO), reduced graphene oxide (rGO)–silver nanoparticles (AgNPs), and their composite structures. The GO-rGO-AgNPs exhibited potent anticancer properties as evidenced by cell culture assays, spheroid formation assay, and quantitative RT-PCR analysis. Treatment of breast cancer cells (MCF-7) with GO, rGO, and AgNPs significantly reduced cell proliferation and mammosphere formation. Furthermore, these treatments downregulated the expression of marker genes associated with CSCs in MCF-7 cells. Among the tested materials, rGO-AgNP, sodium citrate-mediated GO-AgNP, and rGO-AgNP nanocomposites demonstrated superior inhibitory effects on cell survival compared to GO alone. These findings suggest that these nanocomposites hold promise as effective and non-toxic therapeutic agents for targeting cancer cells and CSCs, thereby offering a novel approach to cancer treatment. Full article
(This article belongs to the Special Issue Advances in Drug Delivery in Cancer Treatment)
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Review

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23 pages, 7504 KB  
Review
Mesenchymal Stem Cell-Mediated Targeted Drug Delivery Systems for Hepatocellular Carcinoma: Current Advances and Future Directions
by Yang Gao, Jian-Ping Wang, De-Fei Hong, Chang Yang and Hua Naranmandura
Bioengineering 2025, 12(11), 1206; https://doi.org/10.3390/bioengineering12111206 - 4 Nov 2025
Abstract
Hepatocellular carcinoma (HCC) ranks as the second most lethal malignancy worldwide, presenting formidable therapeutic challenges including tumor heterogeneity, complex microenvironment, and inefficient drug delivery. Conventional therapies such as surgery, chemotherapy, and immunotherapy are limited by systemic toxicity, drug resistance, and poor targeting specificity. [...] Read more.
Hepatocellular carcinoma (HCC) ranks as the second most lethal malignancy worldwide, presenting formidable therapeutic challenges including tumor heterogeneity, complex microenvironment, and inefficient drug delivery. Conventional therapies such as surgery, chemotherapy, and immunotherapy are limited by systemic toxicity, drug resistance, and poor targeting specificity. Mesenchymal stem cells (MSCs) have emerged as promising drug delivery vehicles, leveraging their innate tumor-homing capacity, immunomodulatory properties, and exosome-mediated cargo transport. Preclinical studies demonstrate that MSC-based systems triple drug accumulation in tumors and synergize with immunotherapy, extending survival in HCC models. This review systematically examines recent advances in MSC-based delivery systems for HCC, focusing on engineering strategies to enhance targeting precision and controlled drug release, including genetic modification, exosome engineering, and stimuli-response systems. Despite progress, challenges such as MSC heterogeneity and scalable production persist. Emerging solutions like single-cell RNA sequencing for subpopulation selection and 3D bioprinting for standardized culture are highlighted. This work provides a roadmap for developing MSC-based precision therapies, bridging translational gaps in HCC treatment. Full article
(This article belongs to the Special Issue Advances in Drug Delivery in Cancer Treatment)
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