From Resorption to Regeneration: Innovation in Microsurgical Endodontics

Dear Colleagues,

Endodontic microsurgery has evolved toward biologically centered, minimally invasive interventions that prioritize tissue regeneration over resection. Modern techniques integrate bioceramic materials, guided regeneration protocols, and precision access to restore pulpal, periodontal, and periapical tissues. This shift enables predictable management of complex defects, including root resorption lesions and apico-marginal communications, through three-dimensional repair and functional tissue engineering. Topics of interest for this Special Issue include, but are not limited to, the following:

1. Regenerative Endodontic Procedures and Vital Pulp Therapy
• Bioceramic sealers, scaffolds, and obturation systems;
• Blood clot induction, PRP/PRF, and cell-homing techniques;
• Pulpal revascularization biology (SCAP, signaling factors);
• Vital pulp therapy in mature teeth: materials and outcomes.

2. Tissue Engineering in Surgical Endodontics
• Guided bone regeneration and connective tissue grafting for apico-marginal defects;
• Bioceramic root-end fillings and resorption defect repair (MTA, BC putty, next-generation formulations);
• Grafting strategies for large resorptive defects and periodontal reconstruction;
• Surgical crown lengthening to reestablish biologic width.

3. Root Resorption: Regenerative Management Strategies
• Heithersay and CBCT-based classification guiding treatment selection;
• Minimally invasive surgical access and defect detoxification;
• Bioceramic restoration of resorptive defects using bioactive calcium silicate materials;
• Factors affecting healing and long-term stability.

4. Technology-Assisted Regenerative Workflows
• CBCT and navigation-integrated imaging for precise defect mapping;
• AI-assisted detection and treatment planning;
• Static/dynamic guidance for minimally invasive access preserving viable tissue.

Original research articles, reviews, and well-documented case reports with enough subjects are welcome.

Dr. Mohammad A. Sabeti
Guest Editor

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• endodontic microsurgery
• apico-marginal defects
• regenerative endodontics
• root resorption
• surgical root repair
• external resorption management
• scaffold-based regenerative strategies