Mechanical, Cellular and Molecular Mechanisms on Heart Valve Disease
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 2221
Special Issue Editors
Interests: calcific aortic valve disease; mitral valve disease; ex vivo flow models; hemodynamics
Interests: bioprinting; mechanobiology; 3D printing; aortic valve; calcification; microdissection; calcific aortic valve disease
Special Issue Information
Dear Colleagues,
Heart valve disease affects about 2.5% of the population, with increasing prevalence at older age. No pharmacological treatment exists as of yet, and surgical repair or replacement is the only therapeutic option. Although our understanding of the molecular and cellular mechanisms involved in heart valve disease has greatly expanded in recent years, the complexity of the valvular structure and dynamics and the multifactorial nature of heart valve disease have hampered the development of nonsurgical treatments. The cardiac valves consist of a heterogeneous cell population which resides in a highly organized extracellular matrix. The positioning of the valves in the heart and their specific configuration exposes each part of the leaflet to unique mechanical stresses during the cardiac cycle. Insight into the interaction between the valvular cells, extracellular matrix, and its mechanical environment is crucial for the understanding of the pathophysiology of heart valve disease.
In this Special Issue, we welcome original research papers and review articles on the mechanical, cellular, and molecular mechanisms involved in heart valve disease with an emphasis on the interactions between valvular cells and their environment, new model systems, and new targets for pharmacological therapies.
Dr. Boudewijn Kruithof
Prof. Dr. Elena Aikawa
Guest Editors
Manuscript Submission Information
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Keywords
- heart valve disease
- aortic valve
- mitral valve
- calcific aortic valve disease
- mitral valve prolapse
- valvular interstitial cells
- mechanical environment
- hemodynamics
- myxomatous valves
