Advances in Cancers and Tumor Targeted Immunotherapy

Dear Colleagues,

Cancer is a disease of abnormal gene expression, gene mutations, or dramatic changes in gene regulation. Combination therapy and immunotherapy, offers a path to enhanced outcomes, exemplified by groundbreaking approaches like CAR T-cell therapy. However, the field faces significant challenges, including tumor heterogeneity, variable patient responses, and the development of treatment resistance and disease recurrence. A primary driver of this resistance is the resilience of cancer stem cells (CSCs), which are often resistant to traditional treatments and contribute to disease relapse. Moreover, the intricate interplay between the tumor microenvironment and immune cells can lead to chemoresistance, undermining both chemotherapy and immunotherapy. Overcoming hurdles in cancer treatment and optimizing personalized therapies requires a critical comprehension of the tumor’s intricate nature.

We welcome Review and Research Articles exploring advances in Cancer research and treatment. Submissions should prioritize innovative and non-invasive strategies, such as studies on Cancer Stem Cells, the development of CAR-T therapies, CAR NK therapy, computational modeling, and the application of Artificial Intelligence (AI) methods for cancer diagnosis and therapy.

Dr. Kaushlendra Tripathi
Dr. Kulbhushan Sharma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.