Advances in Natural Product Chemistry and Pharmacology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 839

Special Issue Editors

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Interests: natural product chemistry; biotransformation

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Guest Editor
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Interests: natural product chemistry; alkaloid; analgesic

Special Issue Information

Dear Colleagues,

Natural products are the most abundant sources for providing unaccountable components with a huge diversity of structures, shedding light on the discovery of new active compounds. Since the last century, many medicinal plants have been well studied. However, it remains significant to continue exploring new secondary metabolites from natural sources and to evaluate their potential.

Moreover, it is also important to generalize the dominant class of natural products from the same species, genus, and family, the same subclass from different sources, and different compounds with the same biological activities, to highlight their natural properties and point out targets in the future. 

This Special Issue will focus on:

  1. research articles on new natural products and their biological activities
  2. review well-known important medicinal plant species or genus
  3. review certain subclass of natural products and their therapeutic potentials
  4. review natural products having particular biological activities

Dr. Yan Wang
Dr. Chunlei Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • biological activity
  • species
  • genus
  • subclass

Published Papers (1 paper)

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Research

14 pages, 2805 KiB  
Article
Two Gracilioethers Containing a [2(5H)-Furanylidene]ethanoate Moiety and 9,10-Dihydroplakortone G: New Polyketides from the Caribbean Marine Sponge Plakortis halichondrioides
by Luis A. Amador, Abimael D. Rodríguez, Lesly Carmona-Sarabia, Emilee E. Colón-Lorenzo and Adelfa E. Serrano
Appl. Sci. 2024, 14(1), 281; https://doi.org/10.3390/app14010281 - 28 Dec 2023
Viewed by 485
Abstract
Gracilioether M (6) and 11,12-dihydrogracilioether M (7), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G (9) and its new naturally occurring derivative 9,10-dihydroplakortone G (8), were isolated from the Caribbean marine sponge [...] Read more.
Gracilioether M (6) and 11,12-dihydrogracilioether M (7), two polyketides with a [2(5H)-furanylidene]ethanoate moiety, along with known plakortone G (9) and its new naturally occurring derivative 9,10-dihydroplakortone G (8), were isolated from the Caribbean marine sponge Plakortis halichondrioides. The structures and absolute configuration of 6, 7, and 8 were characterized by analysis of HRESIMS and NMR spectroscopic data, chemical derivatization, and side-by-side comparisons with published NMR data of related analogs. Compounds 6 and 7 and a mixture of 8 and 9 were evaluated for cytotoxicity against MCF-7 human breast cancer cells. In addition, the in vitro antiplasmodial activity against Plasmodium berghei of these compounds was scrutinized using a drug luminescence assay. Full article
(This article belongs to the Special Issue Advances in Natural Product Chemistry and Pharmacology)
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