Special Issue "Nanomaterials for Bone Tissue Engineering"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 1 January 2019

Special Issue Editors

Guest Editor
Dr. Zufu Lu

School of Aerospace, Mechanical, and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia
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Interests: bone tissue regeneration; cell¬–biomaterial interactions, stem cell fate determination; microenvironment
Guest Editor
Prof. Dr. Hala Zreiqat

Faculty of Engineering, The University of Sydney, NSW 2006, Australia
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Phone: +61-2-9351-2392
Interests: nanomaterial; 3D printing; stem cell and tissue regeneration; bioceramics
Guest Editor
Dr. Yogambha Ramaswamy

School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia
Website | E-Mail
Interests: mechanobiology; bone tissue engineering; biomaterials; macromolecules

Special Issue Information

Dear Colleagues,

Regenerating critical-sized bone defects or repairing non-union bone fractures remains a significant challenge in the orthopedic society.  There is a great need to develop new and effective approaches to replace the current “gold-standard” treatment consisting of bone autograft, which might result in complications, such as infection and donor-site morbidity. Over the last twenty years, much efforts have been directed to bone tissue engineering approaches, which involve three key players: (1) scaffold, (2) cells, and (3) soluble factors. As one of the key cornerstones of bone tissue engineering, a desired scaffold should satisfy requirements such as biodegradability, strong mechanical properties, and osteoinductivity and/or condunctivity, the latter important in promoting the desirable cell phenotype (e.g., osteoblasts).

Given that bone is a nanomaterial composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from the macroscale to the nanoscale, the bone scaffold has to mimic the chemical and/or physical characteristics of the bone extracellular matrix (ECM). This will result in nanostructured scaffolds with the desirable architectural, topographical, and mechanical properties. Such scaffolds with structural similarity to the native bone architecture can regulate cell proliferation, differentiation, and migration, leading to the formation of functional tissues. 

In this Special Issue, we invite investigators to contribute original research as well as review articles related to developing nanomaterials for bone tissue regeneration. The topics include, but are not limited to:

  • Design, synthesis, and functionalization of composite biomaterials/nanobiomaterials for bone tissue regeneration;
  • Innovative nanomaterials that can mimic the bone extracellular matrix (ECM) to control stem cell fate for bone tissue regeneration;
  • Applications of nanomaterials as drug-delivering platforms and nucleotides-delivering vehicles for bone tissue regeneration;
  • Applications of nanomaterials for cell labeling and tracking.

Dr. Zufu Lu
Prof. Dr. Hala Zreiqat
Dr. Yogambha Ramaswamy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bone tissue engineering
  • nanomaterials
  • nanoparticles
  • stem cells

Published Papers

This special issue is now open for submission.
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