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Applied Sciences
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Analysis of Drugs in Complicated Matrices: Latest Advances and Prospects
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Analysis of Drugs in Complicated Matrices: Latest Advances and Prospects

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5818

Special Issue Editors

Prof. Dr. Su Zeng

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Interests: pharmaceutical analysis; bio-pharmaceutical analysis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lushan Yu

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Interests: bio-pharmaceutical analysis; drug impurity analysis; drug quality control

Special Issue Information

Dear Colleagues,

The development of pharmaceutical analysis methods has become very important for studying pharmaceutical science and technology. This Special Issue will focus on recent research and developments in multidisciplinary methods of pharmaceutical analysis used to investigate pharmacodynamics, drug quality control, drug toxicity, drug metabolism, and pharmacokinetics (DM/PK).

For many analysts, the analysis of stereoisomers, elements, microorganisms, genotoxic impurities, etc. in chemical drugs, biologic drugs, and herbal medicine (HM), and the analysis of drug metabolites and biomarkers in various species, including animals and plants, represent significant challenges because the sample matrices are extremely complicated. Hence, there is a technical barrier regarding isolation and extraction of the compounds or multiple-components, identification and elucidation of structures, and reliable quantitative contents analysis for those compounds of interest at trace levels. Analytical techniques are being developed with increasing selectivity and sensitivity, visualization, high throughput, real-time and online measurement, etc. to promote drug R&D and quality control.

Prof. Dr. Su Zeng
Prof. Dr. Lushan Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drug impurities
  • Herbal medicine
  • Biologics
  • Metabolites
  • Biomarkers
  • Bioactivity
  • Isolation and extraction
  • Structure elucidation
  • Multiple-components analysis
  • Process analytical technology
  • Visualization
  • High throughput

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Published Papers (2 papers)

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Research

9 pages, 1002 KiB  
Article
Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Quantitative Determination of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide in Dog Plasma
by Li Ping, Xinwei Dong, Minjuan Zuo, Yawen Hong and Difeng Zhu
Appl. Sci. 2022, 12(1), 158; https://doi.org/10.3390/app12010158 - 24 Dec 2021
Viewed by 2185
Abstract
The PI3K/AKT/MTOR signalling pathway plays an important role in the growth and proliferation of tumour cells. N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691) is a new-generation selective AKT inhibitor developed at Zhejiang University. In this study, we developed an ultra-performance liquid [...] Read more.
The PI3K/AKT/MTOR signalling pathway plays an important role in the growth and proliferation of tumour cells. N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691) is a new-generation selective AKT inhibitor developed at Zhejiang University. In this study, we developed an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the measurement of Hu7691 in dog plasma. Plasma was precipitated with acetonitrile and then separated on a trifunctionally bonded alkyl column. Excellent separation efficiency and selectivity were achieved by adjusting the mobile phase ratio, with a total running time of only 5 min. The linear dynamic range of the calibration curve was 5–1000 ng/mL. The method was fully validated, and all performance metrics met the criteria. The validated method was used for the pharmacokinetic monitoring and bioavailability assessment of Hu7691 in dogs. The results showed that the area under the curve and peak plasma concentration of Hu7691 increased with increasing dose (oral 5, 10, 20 mg/kg, intravenous 10 mg/kg), and oral bioavailabilities were 86.7%, 50.8%, and 50.5%, respectively, indicating a high bioavailability of Hu7691 in dogs. This provides a test basis for the clinical application of the compound. Full article
(This article belongs to the Special Issue Analysis of Drugs in Complicated Matrices: Latest Advances and Prospects)
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12 pages, 4449 KiB  
Article
The Metabolic Stability of Antimicrobial Peptides IK8 in Plasma and Liver S9
by Yingying Mao, Shaojun Zhou, Mingcheng Xu, Su Zeng, Weimin Fan, Lushan Yu and Nengming Lin
Appl. Sci. 2021, 11(24), 11661; https://doi.org/10.3390/app112411661 - 8 Dec 2021
Cited by 2 | Viewed by 2721
Abstract
In the face of mounting global antibiotic resistance, which has become a critical clinical problem, antimicrobial peptides (AMPs) have received considerable interest as new therapeutics with the efficacy for the treatment of multidrug-resistant (MDR) infections due to their novel mechanism. However, certain inherent [...] Read more.
In the face of mounting global antibiotic resistance, which has become a critical clinical problem, antimicrobial peptides (AMPs) have received considerable interest as new therapeutics with the efficacy for the treatment of multidrug-resistant (MDR) infections due to their novel mechanism. However, certain inherent shortcomings such as instability seriously limit their systemic applications in the clinic. In this study, we intend to clarify the connection between three configurations of IK8 and their stability in plasma and liver S9 of various species by confirming the metabolites. The structural information of these metabolites was scanned and identified using HPLC and Q-TOF, respectively. The results found that IK8-D exhibits superior stability, compared with IK8-2D and IK8-L in plasma and liver S9 incubation, which indicated D- type amino acids could significantly increase the stability of antimicrobial peptides. Full article
(This article belongs to the Special Issue Analysis of Drugs in Complicated Matrices: Latest Advances and Prospects)
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