Advanced Biomaterials in Bone Defect Healing

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (16 August 2021) | Viewed by 352

Special Issue Editor

Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA
Interests: biomaterials; tissue engineering; bone; stem cells; polymers; bone healing

Special Issue Information

Dear Colleagues,

We are in a truly exciting time due to the rapid expansion of the field of biomedical engineering, including advances in stem cell biology, material science, polymer design, and development, and the integration of biological, chemical, electronical, and mechanical technologies. For bone tissue engineering, these components must come together synergistically under the right biological cues to generate a balanced “microenvironment” for the proliferation and differentiation of resident cells (or transplanted cells) to heal a boney defect. Biomaterials play a crucial role in regeneration and repair of bone, especially when the size of a defect extends beyond the body’s ability to heal spontaneously. They must be able to support cellular proliferation and differentiation, provide a sufficient amount of “space” for bone and all other supportive cells to migrate into, and promote a radiolucent environment to enable real-time radiographic monitoring of bone repair and regeneration. Obviously, biocompatibility, immunogenicity, tumorigenicity, and the degradation profile of the biomaterial must be evaluated to ensure patient safety. In addition, there may be many properties that specifically affect bone healing such as compressibility, elasticity, mechanical strength, and porosity. This Special Issue will bring together papers that focus on biomaterials designed and developed to address issues surrounding repair and regeneration of bone including but not limited to the following:

  • Design, development, and fabrication of novel scaffolds or biomaterials for bone healing;
  • Fate of resident or transplanted stem and progenitor cells in scaffolds after implantation;
  • In vivo imaging of biomaterials or scaffolds during bone healing;
  • Preclinical and clinical studies on biomaterials for bone repair and regeneration;
  • Mechanical properties of various biomaterials specifically designed for bone repair and regeneration;
  • Role of biomaterials and scaffolds in the reconstitution of damaged bone microenvironment;

Interaction between various biological cues such as growth factors and biomaterial to promote bone healing.

Prof. Charles C Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • scaffolds
  • bone
  • microenvironment
  • bone repair
  • regeneration
  • healing
  • stem and progenitor cells
  • preclinical and clinical studies

Published Papers

There is no accepted submissions to this special issue at this moment.
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