Novel Insight into Mechanisms of Bioactive Compounds and Its Use in the Prevention and Treatment of Thromboinflammation
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 6789
Special Issue Editor
Interests: cardiovascular pharmacology; protein bio—chemistry; signal transduction; platelet biology; anti-thrombotic drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The close connection between inflammatory and thrombotic processes is presumed to have an evolutionary origin, as injuries need both an efficient hemostasis and an inflammatory immune response against entering pathogens. Behind vasoconstriction, platelets are the first immunomodulatory cells at the side of injury closing damaged blood vessels by aggregation and forming a thrombus. Thus, platelets promote inflammatory activity by an intimate crosstalk with leukocytes: in the case of vascular injury, neutrophils or monocytes are suggested to interact with endothelium-adherent platelets. Thus, platelets coordinate the inflammatory response by controlling the additional adhesion of innate immune cells to the inflamed endothelium, which is considered serious for the atherosclerotic disease process. For example, macrophage pro-inflammatory cytokine secretion is enhanced following interaction with activated platelets, proposing that the presence of activated platelets at sites of inflammation aggravates pro-inflammatory macrophage activation. The diversity of platelet receptors contributing to platelet interactions reveals various interesting targets within the context of platelet-mediated inflammation. Since a broad range of recent experimental methodologies indicate that platelets contribute to the pathogenesis of stroke-associated inflammation, the targeting of inhibiting mechanisms, which is involved in platelet activation, thromboembolism and its related inflammation is important to prevent thromboinflammatory diseases. Although many natural phytomedicine with potent anti-inflammatory properties have been noted as reasonable approaches for clinical trials, inadequate effort has been directed towards finding the molecular mechanisms underlying the therapeutic efficacy against thromboinflammatory events. Therefore, we invite authors to contribute their original research as well as review articles focused on understanding the molecular mechanisms of natural or synthetic bioactives on antithrombotic and inflammatory responses.
Potential topics include but are not limited to:
- Antiplatelet and antithrombotic mechanism of bioactive compounds;
- anti-inflammatory role and therapeutic mechanism of natural bioactives;
- the neuroprotective role of bioactive substances.
Prof. Dr. Joen-Rong Sheu
Guest Editor
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Keywords
- bioactive compounds
- phytomedicines
- antiplatelet
- thromboinflammation
- neuroprotection
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