Anti-infective Properties of Natural Products
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1954
Special Issue Editors
Interests: PCR; antimicrobials; microbial molecular biology; molecular microbiology
Special Issues, Collections and Topics in MDPI journals
Interests: bacteria; quorum sensing; resistance; virulence; drug repurposing; stress response; social cheating
Special Issue Information
Dear Colleagues,
The bullish rise of drug resistance among pathogens has raised serious alarms regarding the treatment of infections. Drug resistance to antimicrobial agents has made current antibiotic therapies ineffective, leading to persistent infections that have incurred huge economic losses. There is thus an urgent need for novel antimicrobial agents able to counter the menace of antimicrobial drug resistance (AMR). Some alternative strategies for dealing with drug resistance include targeting the resistance mechanisms, such as inhibiting efflux pumps or beta-lactamases. Further, some approaches act on the virulence functions, quorum sensing and biofilms of pathogens and render them ineffective. These antimicrobial strategies reduce selective pressure on the microbial pathogens, eventually leading to decreased resistance.
Lead compounds for overcoming antimicrobial drug resistance from various natural products are well documented. In the last 35 years, around 60% natural-product-derived antibacterial, antifungal, antiviral and antiparasitic drugs have been approved by the US Food and Drug Administration. Yet only a small number of natural products have been explored for anti-infective properties against pathogenic microbes. This Special Issue aims to shed light on recent discoveries of novel anti-infectives from natural products, including their mechanisms of actions, in silico studies, synergistic action with known drugs and in vivo studies. We welcome research as well as review articles for this Special Issue.
Dr. Fohad Mabood Husain
Dr. Rodolfo Garcia-Contreras
Guest Editors
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Keywords
- natural products
- anti-infectives
- virulence
- drug resistance
- efflux pump
- quorum sensing
- biofilm
- synergy
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