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Lasers in Biophotonics and Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (20 December 2025) | Viewed by 752

Special Issue Editor


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Guest Editor
Electronic Technology Department, Universidad Carlos III de Madrid, 28911 Leganés, Madrid, Spain
Interests: optoelectronic; laser technology; biomedical applications; biophotonics; biomedical optics

Special Issue Information

Dear Colleagues,

The advent of the laser, beginning with the first demonstration by Theodore Maiman in 1960, represents a significant milestone in biophotonics and biomedical applications. Lasers offer high precision in imaging and diagnostics such as in optoacoustic or photoacoustic tomography (OAT or PAT), optical coherence tomography (OCT), diffuse optical tomography (DOT), fluorescence optical imaging (FOI), laser Doppler imaging (LDI) and Raman spectroscopy and in minimally invasive therapeutic techniques such as photodynamic therapy (PDT), photothermal therapy (PTT) and low-level laser therapy (LLLT). It is important to note that the application of fluorescence and photoacoustic dual-modality imaging for hypoxia in living cells plays a significant role in tumor hypoxia. In this context, the combination of diagnostics (imaging) and therapeutics, theragnosis, to achieve a more precise and targeted approach to disease management, particularly cancer, is emerging as an important field for the future of lasers in biophotonics and biomedical applications. This area is poised for further innovation driven by emerging technologies including nanotechnology and artificial intelligence (AI): nanotechnology, through the interaction of lasers with nanoparticles, will create more effective and less invasive methods for drug delivery and cancer treatment, while AI will increase the precision of imaging and diagnostics following the acquisition of patient-specific results. By this means, the combination of nanotechnology and AI holds immense potential for scientific and technological advancements in lasers within the context of biophotonics and biomedical applications.

Prof. Dr. Horacio Lamela Rivera
Guest Editor

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Keywords

  • laser
  • biology
  • imaging and diagnosis
  • therapy
  • theragnosis
  • tumor hypoxia
  • nanotechnology
  • cancer

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Published Papers (1 paper)

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Research

14 pages, 2359 KB  
Article
Efficacy of Photothermal Duodenal Mucosal Ablation (PDMA) on Glycemic Control in a Type 2 Diabetic Rat Model
by Seonho Jung, Van Gia Truong, Myungji Kang and Hyun Wook Kang
Appl. Sci. 2026, 16(4), 1788; https://doi.org/10.3390/app16041788 - 11 Feb 2026
Viewed by 461
Abstract
The current study aims to evaluate the efficacy and safety of photothermal duodenal mucosal ablation (PDMA), utilizing a 1470 nm wavelength and a diffusing fiber (DF), in ex vivo liver tissues and an in vivo type 2 diabetes mellitus (T2DM) rat model. The [...] Read more.
The current study aims to evaluate the efficacy and safety of photothermal duodenal mucosal ablation (PDMA), utilizing a 1470 nm wavelength and a diffusing fiber (DF), in ex vivo liver tissues and an in vivo type 2 diabetes mellitus (T2DM) rat model. The 1470 nm laser with the DF was used for uniform duodenal mucosal ablation. After optimizing dosimetry (9–49 J) ex vivo, PDMA was performed on twelve T2DM rats (n = 4 per group) induced by a high-fat diet and streptozotocin. Glycemic metabolism and histological changes were monitored for 14 days. All experimental data were analyzed using the Mann–Whitney U test for statistical significance. Optimized PDMA (5 W for 5 s) achieved uniform, circumferential mucosal ablation while preserving outer layers. Histology assessment confirmed optimal ablation at day 2 with substantial regeneration by day 14. Consequently, the PDMA group showed significantly improved glycemic indexes at day 14 compared to the sham control. Therefore, the proposed PDMA may be promising in remodeling the duodenal mucosa for glycemic control in T2DM. Future research will evaluate the PDMA in a larger number of animals to warrant efficacy and safety for clinical translation. Full article
(This article belongs to the Special Issue Lasers in Biophotonics and Biomedical Applications)
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