Advanced Chemotherapeutic Technologies
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 143
Special Issue Editor
2. Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warszawa, Poland
Interests: chemotherapy and targeted therapy of gastrointestinal malignancies; geriatric oncology; artificial intelligence in oncology; clinical trials; public health in oncology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chemotherapy is one of the three basic methods of oncological treatment alongside cancer surgery and radiation therapy, although the range of other therapeutic methods used is expanding (e.g., nuclear medicine, hyperthermia). Cancer chemotherapy is a systemic oncological treatment that employs cytostatic drugs, usually administered as part of a treatment regimen. It is often combined with other anticancer treatments, especially surgery, radiation and hormone therapy, and treatment targeting specific processes of cancer cells. Chemotherapy may use a single drug (monotherapy) or, more commonly, a combination of multiple drugs (polychemotherapy) arranged in a treatment program outlining the drug types, their doses, dosing intervals, route of administration, and ancillary drugs.
Anticancer chemotherapy does not have the same spectacular record as that for infectious diseases, and opportunities to improve its effectiveness are constantly being sought. The main obstacles to clinical efficacy are toxic effects in normal tissues and the development of tumor resistance to the administered drugs. One way to overcome these problems is to improve the drugs we know and use. This can be achieved by either looking for new derivatives with a better therapeutic index and a more convenient administration route, that is, improving known drug molecules, or by seeking new, better formulations, changing, for example, the solvent, PEGylating the molecule, or placing it in a liposome. Yet another way to overcome these challenges is the use of existing drugs for new therapeutic indications. New technologies, such as artificial intelligence, are being used to advance chemotherapy efficacy.
Dr. Krzysztof Jeziorski
Guest Editor
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Keywords
- chemotherapy
- targeted therapy
- combined-modality therapy
- advanced chemotherapeutic technologies
- artificial intelligence
- intelligent oncology
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