Biomaterials and Biotechnologies in Oral–Maxillofacial Surgery
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 12
Special Issue Editors
Interests: additive manufacturing; material characterization; biomedical alloys; biomaterials
Special Issues, Collections and Topics in MDPI journals
Interests: dental materials; polymer engineering; composite resins; mechanical properties; tensile testing
Interests: endo-resto; dental composites; dental photography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomaterials and biotechnologies play a pivotal role in advancing oral and maxillofacial surgery, addressing complex reconstructive and regenerative challenges. Biomaterials, including bioactive ceramics (e.g., hydroxyapatite and calcium phosphates), polymers (e.g., polylactic acid and collagen), and composites, are engineered to mimic the physical, chemical, and biological properties of native tissues. They support cellular adhesion, proliferation, and differentiation, crucial in bone regeneration, soft tissue repair, and implantology. Recent advancements have focused on designing biomaterials with controlled porosity, mechanical strength, and surface bioactivity to optimize osseointegration and reduce inflammation. Additionally, 3D printing and bioprinting technologies have enabled the precise fabrication of patient-specific scaffolds with complex geometries, enhancing functional outcomes. Moreover, the integration of biotechnologies, such as stem cell therapies, growth factors (e.g., BMP-2, TGF-β), and extracellular vesicles, has revolutionized tissue engineering by promoting targeted tissue regeneration. Biomarkers, including molecular signals of osteogenesis (e.g., alkaline phosphatase, osteocalcin) and angiogenesis (e.g., VEGF), are increasingly used to monitor the effectiveness of these therapies, providing insights into cellular responses and the microenvironment during healing. Collectively, these innovations aim to improve the predictability and longevity of reconstructive outcomes, reduce recovery times, and enhance the aesthetic and functional quality of life for patients. As the demand for personalized, regenerative approaches grows, this multidisciplinary field remains at the forefront of modern surgical practice.
Dr. Żaneta Anna Mierzejewska
Dr. Michał Krasowski
Dr. Leszek Szalewski
Guest Editors
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Keywords
- biomaterials
- oral–maxillofacial surgery
- tissue engineering
- bone regeneration
- 3D printing
- stem cell therapy
- growth factors
- osseointegration
- biomarkers
- personalized medicine
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