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Analysis, Characterization and Antioxidant Properties of Natural Products

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 4634

Special Issue Editors

Sub-Institute of Agriculture and Food Standardization, China National Institute of Standardization, Beijing 100191, China
Interests: reference material; HPLC; HPLC-MS/MS; natural product; agricultural product; food
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Guest Editor
Department of Science and Environment, Roskilde University, DK-4000 Roskilde, Denmark
Interests: isotope effects in biological systems; intramolecular hydrogen bonding; tautomerism; natural products; theoretical calculations of spectroscopic properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products refer to the components or metabolites of animals, plant extracts, insects, marine organisms, and microorganisms, as well as many endogenous chemical components in human and animal bodies. With the increasing emphasis on health, there is a growing demand for various bioactive natural products, and more natural products are being discovered and utilized.

In this field of research, scientists use various analytical techniques to identify and characterize the chemical components of natural products. These techniques may include chromatography, spectroscopy, nuclear magnetic resonance (NMR), and mass spectrometry, among others. By understanding the chemical structure and composition of these compounds, researchers can gain insights into their potential antioxidant activities.

The antioxidant properties of natural products are often evaluated through various in vitro and in vivo assays. In vitro assays, such as DPPH radical scavenging, ABTS radical scavenging, and ferric reducing antioxidant power (FRAP) assays, measure the ability of a compound to scavenge free radicals or reduce metal ions. In vivo assays, on the other hand, involve the administration of a natural product to living organisms to study its effects on markers of oxidative stress and antioxidant defense systems.

This Special Issue aims to promote research works focused on the analytical techniques, characterization methods, and antioxidant properties research of natural products. All research articles and reviews dealing with extraction, characterization, isolation, and purification, but also the synthesis of natural and nature-derived compounds and their antioxidant properties evaluations in vitro and in vivo, are welcome. Findings dealing with the application of novel natural antioxidants in the maintenance of human well-being and in the prevention of disease are particularly welcome.

Dr. Tao Lan
Prof. Dr. Poul Erik Hansen
Guest Editors

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Keywords

  • natural products
  • analysis
  • characterization
  • application
  • reference material
  • antioxidant
  • health food
  • dietary supplements

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Published Papers (3 papers)

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Research

15 pages, 2373 KiB  
Article
Evaluating the Thymoquinone Content and Antioxidant Properties of Black Cumin (Nigella sativa L.) Seed Oil During Storage at Different Thermal Treatments
by Grażyna Neunert, Wiktoria Kamińska and Joanna Nowak-Karnowska
Appl. Sci. 2025, 15(1), 377; https://doi.org/10.3390/app15010377 - 3 Jan 2025
Viewed by 1569
Abstract
Black cumin seeds (Nigella sativa) and black cumin seed oil (BCSO) exhibit various pharmacological activities, most of which are attributed to the presence of thymoquinone (TQ). TQ, however, is characterized by low stability at elevated temperatures and instability in aqueous environments. [...] Read more.
Black cumin seeds (Nigella sativa) and black cumin seed oil (BCSO) exhibit various pharmacological activities, most of which are attributed to the presence of thymoquinone (TQ). TQ, however, is characterized by low stability at elevated temperatures and instability in aqueous environments. In this study, the spectroscopic properties of TQ were used to monitor changes in TQ content in BCSO subjected to thermal exposure. Simultaneously, the influence of the presence of TQ on the antioxidant properties of this oil was determined. The used spectrofluorimetric and chromatographic method quantified the presence of TQ. The antiradical properties of the oil in different stages of thermal oxidation degradation were determined by the DPPH method. The measured antiradical activity of the oil, depending on the exposure conditions used, revealed the difference correlated with the content of the TQ. However, the presence in BCSO of other bioactive components, like phenols, had a more significant influence on its total antioxidant capacity. Furthermore, our study, for the first time, focused on the rise in TQ content in the oil during thermal storage, indicating a new method to enhance the TQ content in BCSO. Full article
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15 pages, 4209 KiB  
Article
Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier
by Tiantian Wang, Qi Wu, Lihong Wang, Tao Lan, Zhenyu Yun, Lin Zhao and Xi Wu
Appl. Sci. 2024, 14(24), 11732; https://doi.org/10.3390/app142411732 - 16 Dec 2024
Viewed by 1122
Abstract
Nicotinamide mononucleotide (NMN) possesses a variety of physiological functions and has therapeutic effects on cardio-cerebral diseases, senile degenerative diseases, neurodegenerative diseases, delayed aging, etc. However, its ability to cross the blood–brain barrier (BBB) and the mechanism of its transport have not been reported. [...] Read more.
Nicotinamide mononucleotide (NMN) possesses a variety of physiological functions and has therapeutic effects on cardio-cerebral diseases, senile degenerative diseases, neurodegenerative diseases, delayed aging, etc. However, its ability to cross the blood–brain barrier (BBB) and the mechanism of its transport have not been reported. In this study, we used the immortalized hCMEC/D3 cell line to construct an in vitro monolayer cell BBB model, evaluated its ability to cross the blood–brain barrier, and explored the mechanism by carrying out transport and efflux experiments on NMN. The ability of NMN to cross the BBB was investigated by preparing NMN-loaded liposomes conjugated with ANG peptide and RVG peptide. The results showed that the transmembrane transport ability of NMN was moderate, and the transport mechanism was passive transport relying on the concentration difference. The trans-BBB ability of ANG peptide coupled with NMN could be highly significantly improved. Full article
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15 pages, 1026 KiB  
Article
Quality Assessment of Edible Plant-Based Fixed Oils Using Different Analytical Techniques and Machine Learning Approaches
by Irini F. Strati, Konstantinos Tsiantas, Angeliki Psouni, Georgia Ladika, Dionisis Cavouras and Vassilia J. Sinanoglou
Appl. Sci. 2024, 14(22), 10305; https://doi.org/10.3390/app142210305 - 9 Nov 2024
Cited by 1 | Viewed by 1242
Abstract
Plant-based carrier oils are constantly gaining popularity for their beneficial health effects on human organisms, thus shifting consumers’ preferences to alternative options in the oil market. The purpose of the study was to evaluate the quality characteristics of twenty-six edible plant-based fixed oils [...] Read more.
Plant-based carrier oils are constantly gaining popularity for their beneficial health effects on human organisms, thus shifting consumers’ preferences to alternative options in the oil market. The purpose of the study was to evaluate the quality characteristics of twenty-six edible plant-based fixed oils via chromatographic, chromatic, and spectroscopic techniques, suggesting their potential use as complementary edible oil sources. Palmitic, stearic, oleic, linoleic, and a-linolenic acids were found in considerable proportions, whereas the majority of oils possessed unsaturated (UFA)/saturated (SFA) fatty acid ratio greater than 1.6, suggesting their function in lowering blood pressure and preventing cardiovascular disease. Linseed, chia seed, macadamia, and canola oils provide a balanced intake of n-6 and n-3 polyunsaturated fatty acids (PUFA) within the range of 1:1 to 5:1. Oxidative stability was inversely related to oils’ PUFA content, with linseed, chia seed, pine cone, and walnut oils being the least stable oils against oxidation. Chlorophyll content in all oils was below the limit (50 mg/kg), preventing oxidation in the presence of light, whereas the highest values of b-carotene were noticed in soybean, linseed, and canola oils (61.18, 60.42, and 60.12 ppm, respectively). The application of machine learning algorithms for analyzing ATR-FTIR band intensities and FA proportions via discriminant analysis succeeded in discriminating pulp from seed oils, with a classification accuracy of 96.0% and 88.0%, respectively. Full article
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