Innovative Strategies for Combatting Antibiotic Multi Resistance: From Computational Approaches to Clinical Application
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 82
Special Issue Editors
Interests: host–pathogen interaction; virulence factor; inflammation; bacterial pathogens; immunogen; protein–protein interaction
Special Issues, Collections and Topics in MDPI journals
Interests: computational biology; microbial communication; drug repurposing; big data analysis
Interests: MDR; biofilm; Legionella spp; H. pylori
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antimicrobial resistance to multiple drugs, known as multidrug resistance (MDR), is increasing globally. The indiscriminate use of antimicrobials has acted as a selective filter from which drug resistance traits have emerged in almost all microbes living in contact with humans.
MDR is currently one of the main public health threats. Multidrug-resistant human bacterial pathogens (superbugs) are continuously emerging and causing several million deaths worldwide. Prospective studies indicate that superbugs could become the leading cause of death in the coming decades, and currently, the rate of development of new antimicrobials is not keeping pace with rise in MDR. Admittedly, at present, it seems the scientific community are “retreating from the front line”, significantly hindering our capacity to effectively meet unfulfilled therapy needs.
Therapeutic specialists and applied-scientists, in the current fight against evolving superbugs, require up-to-date information, because new and future antibiotics may also face the challenge of developing resistance. This Special Issue will aim to collate and showcase up-to-date research regarding different antibiotic-resistant bacteria, encompassing in silico conditions to the bedside, focusing on omics research and host–pathogen interactions to discover pioneering strategies.
We are therefore welcoming the submission of articles "overlapping" with all aspects of superbug biology and AMR therapy. Potential topics include, but are not limited to, the following:
- Transcriptomics;
- Proteomics;
- Genomics;
- Interatomic forces;
- Pathogen biology;
- Innate immunity and inflammation response;
- Adaptative immunity;
- Nanoparticles and combinatorial drug approaches;
- Quorum sensing;
- Biofilms;
- Computational biology;
- Therapies;
- Infection models.
Dr. Salvatore Papasergi
Dr. Akanksha Rajput
Dr. Teresa Fasciana
Guest Editors
Manuscript Submission Information
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Keywords
- antibiotic resistance
- antimicrobial resistance (AMR)
- multidrug-resistant (MDR) bacteria
- computational biology
- drug discovery
- bioinformatics approaches
- drug repurposing
- quorum sensing inhibitors
- quorum quenching
- efflux pump inhibitors
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