Molecular Characteristics and Genomic Epidemiology of Multidrug-Resistant Gram-Negative Bacteria
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1056
Special Issue Editor
Interests: molecular microbiology; antimicrobial resistance; resistance mechanisms; Enterobacterales; last-line antimicrobials
Special Issue Information
Dear Colleagues,
Multidrug-resistant (MDR) Gram-negative bacteria represent one of the most pressing challenges in modern medicine. Their remarkable ability to acquire and disseminate resistance determinants—through both chromosomal mutations and horizontal gene transfer—has led to the global spread of high-risk clones across healthcare and community settings. Critical pathogens such as Enterobacterales and non-fermenting Gram-negative bacilli are increasingly resistant to “last-resort” antibiotics, including carbapenems, polymyxins, and tigecycline. Understanding the molecular characteristics and genomic epidemiology of these organisms is essential for unraveling their adaptive mechanisms, tracking transmission dynamics, and identifying emerging resistance determinants. Integrating whole-genome sequencing, transcriptomic analyses, and molecular surveillance provides powerful tools to elucidate resistance evolution and guide effective infection control and antimicrobial stewardship strategies.
This Special Issue aims to highlight recent advances in the molecular and genomic understanding of MDR Gram-negative bacteria, emphasizing both clinical relevance and translational potential. It welcomes high-quality original research, review, and perspective articles.
Dr. Piotr Majewski
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- multidrug-resistant gram-negative bacteria
- antimicrobial resistance
- whole-genome sequencing
- molecular epidemiology
- resistance mechanisms
- horizontal gene transfer
- infection control
- antimicrobial stewardship
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