Overcoming Bacterial Resistance Using Antibiotic Combinations
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1592
Special Issue Editors
Interests: in vitro model studies; antibiotic pharmacodynamics; antimicrobial resistance
Special Issue Information
Dear Colleagues,
Resistance of bacteria to antibiotics is a growing problem. One of the existing ways to overcome the emergence of microbial resistance is combined use of antibiotics of different classes and/or antibiotics with beta-lactamase inhibitors. The search of such combinations or new active compounds characterized with potent efficacy against resistant organisms is one of the main areas of research. For these purposes, different approaches based on in vitro activity assay of combinations, including checkerboard techniques, time-kill experiments and investigation of pharmacodynamics in in vitro dynamic models, are used. In vitro dynamic models simulate the human pharmacokinetics of drugs and allow predicting the antibiotic combination effectiveness in clinic. Along with the search for novel antibiotic combinations, new approaches to evaluate their possible efficacy in clinic are valuable. In vivo experiments with infected animals hold a special place in the investigation of perspective drug combinations. Articles exploring the antimicrobial potential of drug combinations to overcome antibiotic resistance are welcome.
Dr. Maria V. Golikova
Dr. Elena N. Strukova
Guest Editors
Manuscript Submission Information
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Keywords
- antibiotic resistance
- antibiotic combinations
- beta-lactamase inhibitors
- novel approaches to predict efficacy of antibiotic combinations
- checkerboard assay
- in vitro time-kill assay
- in vitro dynamic model studies
- antibiotic pharmacodynamics
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