Special Issue "Replacing Animal Testing in Research—A Scientific and Regulatory Perspective of Current Efforts Towards the 1R"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Welfare".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Dania Movia
E-Mail Website
Guest Editor
LBCAM, Trinity Translational Medicine Institute and Department of Clinical Medicine, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
Interests: animal-free research; cancer models; tissue-mimetic in vitro models
Dr. Adriele Prina-Mello
E-Mail Website
Guest Editor
LBCAM, Trinity Translational Medicine Institute and Department of Clinical Medicine, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
Interests: nanomedicine; translational research; medical devices; diagnostics

Special Issue Information

Dear Colleagues,

According to the most recent regulations on animal research across the globe, alternative methods in basic and applied research should replace animals when available. The problem is, alternative methods are meaningless without validation and suitable regulatory applications. This Special Issue aims at initiating a conversation on the role of contemporary replacement research and on how barriers to its implementation can be overcome in practice. It focuses on highlighting current state-of-the-art and cutting-edge developments that have the potential to replace animal tests in any research and educational field. This includes, for example, alternative methods developed for biomedical research in the toxicology, product safety and drug discovery/development fields, techniques implemented in alternatives methods (e.g., 3D bioprinting, micro- and milli-fluidics), as well as alternative methods for teaching, towards the aim of creating humane education. Other associated topics that are also of interest for this Special Issue are:

  • The validation process and regulatory acceptance of alternative methods, where the field should be heading, and how to speed the process.
  • Perspectives on potential concerns towards the 1R from the regulatory, scientific and industrial point-of-view.
  • Identification of priorities to reduce animal use in biomedical research (including addressing concerns related to the need of more research for aiming towards the 1R).
  • Description of tools (e.g., systematic reviews, databases, etc.) supporting the use of alternative methods/models as biotechnological resources.
  • Examples of how alternative models can be developed and promoted as key enabling biotechnology to stimulate innovation and growth in a variety of sectors.
  • The mission and achievements of existing 3Rs Centers across the world, with specific emphasis on education, training and research initiatives supported by these centers.
  • Quality and ethical aspects of animal replacement.

Commentaries, reviews and original manuscripts that address one or more of the topics listed above are invited for this Special Issue.

Dr. Dania Movia
Dr. Adriele Prina-Mello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal replacement
  • biomedical research
  • education and training
  • new approach methodologies

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Protecting Canada's Lab Animals: It's Time For Legislation
Authors: Dr. Elisabeth Ormandy 1; Dr. Charu Chandrasekera 2; Camille Labchuk 3
Affiliation: 1 Canadian Society for Humane Science
2 Canadian Centre for Alternatives to Animal Methods (CCAAM)
3 Animal Justice

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