Intestinal Immunity, Oxidative Stress, and Gut Microbiota: Mechanisms and Nutritional Interventions in Swine

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue of Animals (MDPI) focusing on swine intestinal health. Swine intestinal health is critical for efficient production and animal welfare, as intestinal immunity imbalances and oxidative stress often trigger diseases (e.g., post-weaning diarrhea), while the gut microbiota acts as a core regulator of these processes. However, systematic research on the synergistic mechanisms among the gut microbiota, intestinal immunity, and oxidative stress, as well as targeted nutritional interventions, remains to be strengthened—making this research area highly valuable for both basic science and industry practice.

This Special Issue aims to gather high-quality studies that clarify the intricate interactions between swine intestinal immunity, oxidative stress, and the gut microbiota, decode their underlying molecular/physiological mechanisms, and highlight effective nutritional interventions. It aligns with Animals’ scope (covering animal science, nutrition, and health) to bridge basic research and practical applications, providing insights for optimizing swine production.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

Mechanisms by which gut microbiota/metabolites (e.g., SCFAs, bile acids) regulate swine intestinal immune responses (e.g., macrophage activation, cytokine secretion).

Pathways of oxidative stress (e.g., weaning/transport stress) affecting swine gut microbiota diversity and intestinal barrier function.

The efficacy and mechanisms of functional nutrients (e.g., probiotics, plant extracts, and precision amino acids) modulating the gut microbiota–immunity–oxidative stress axis.

Dynamic changes in the above processes in specific swine stages (e.g., piglets, finishers) and corresponding nutritional strategies.

The application of multi-omics (metagenomics, transcriptomics) in analyzing swine intestinal health mechanisms.

I look forward to receiving your contributions.

Dr. Yuanzhi Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.