Health of the Ovaries, Uterus, and Mammary Glands in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 675

Special Issue Editors

School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China
Interests: reproduction; endocrine; metabolism; toxicology
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun 130062, China
Interests: intestinal flora; mammitis; hysteritis; dysreproductive disease
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Special Issue Information

Dear Colleagues,

The health of the ovaries, uterus, and mammary glands is of paramount importance in livestock production. These organs are crucial in successful reproduction, lactation, and overall animal well-being. Optimal reproductive function directly translates to improved fertility rates, increased milk yields, and enhanced economic viability in livestock operations. However, various factors, including genetic predisposition, nutritional deficiencies, infectious diseases, and environmental stressors, can significantly compromise the health of these vital organs. This can lead to a cascade of negative consequences, such as infertility, embryonic mortality, reduced milk production, and increased susceptibility to other diseases. Consequently, understanding the complex interplay of factors that influence reproductive health and developing effective strategies to enable its maintenance are critical in ensuring sustainability and profitability in modern livestock farming.

This Special Issue will provide a platform for researchers to share their latest findings on the physiology, pathology, and management of the female reproductive system in livestock species. We invite submissions addressing fundamental and applied aspects of reproductive biology, including the impact of genetic, nutritional, and environmental factors, the development of novel diagnostic tools, the evaluation of therapeutic interventions, and the pathogenesis and treatment of female reproductive disorders.

Dr. Diqi Yang
Dr. Xiaoyu Hu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • livestock reproduction
  • reproductive health
  • ovary
  • uterus
  • mammary gland
  • reproductive diseases
  • fertility
  • lactation
  • animal welfare

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Published Papers (1 paper)

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Research

13 pages, 12971 KiB  
Article
The Role of Gonadotropins and Growth Factor in Regulating Ras During Maturation in Cumulus–Oocyte Complexes of Pigs
by Eunju Seok, Minyoung Son, Seunghyung Lee, Hee-Tae Cheong and Sang-Hee Lee
Animals 2025, 15(14), 2100; https://doi.org/10.3390/ani15142100 - 16 Jul 2025
Viewed by 396
Abstract
Oocytes and cumulus cells undergo meiotic resumption and proliferation via gonadotropins and growth factors during maturation, and various small G proteins are activated when COCs undergo physiological changes. This study investigated the influence of gonadotropins and growth factors on Ras and its GTPases [...] Read more.
Oocytes and cumulus cells undergo meiotic resumption and proliferation via gonadotropins and growth factors during maturation, and various small G proteins are activated when COCs undergo physiological changes. This study investigated the influence of gonadotropins and growth factors on Ras and its GTPases during porcine COC maturation. Unmatured COCs were treated with FSH, LH, or EGF for 44 h. The mRNA expression levels of the Ras subfamily (H-Ras, K-Ras, N-Ras, and R-Ras), its GTPases (RASA1 and SOS1), and proliferation factors (ERK, CCNB1, and Cdc2) were analyzed using RT-PCR. In contrast to other Ras subfamilies, R-Ras expression is upregulated during COC maturation. We evaluated the effects of FSH, LH, and EGF at various concentrations that most effectively regulated the expression of R-Ras and GTPases. The results demonstrated that 0.5 µg/mL FSH, 10 IU/mL human chorionic gonadotropin (hCG), and 10 ng/mL EGF effectively enhanced R-Ras expression and cell proliferation. FSH supplementation during porcine COC maturation significantly upregulated R-Ras and ERK expression, independent of LH and EGF, and downregulated Cdc2 expression. These results indicated that FSH regulates R-Ras expression, thereby promoting cell proliferation during COC maturation. These results provide fundamental knowledge for understanding the role of Ras and its family members in the development of follicular environments in pigs. Full article
(This article belongs to the Special Issue Health of the Ovaries, Uterus, and Mammary Glands in Animals)
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