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Animals
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Surgical Oncology in Companion Animals
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Surgical Oncology in Companion Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 17083

Special Issue Editor

Dr. Roberta Ferrari

E-Mail Website
Guest Editor
Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy
Interests: small animal; oncology; surgery; wound management; mast cell tumor; sarcoma

Special Issue Information

Dear Colleagues,

I’m very honored to invite You to submit articles in this special issue of Animals focused on surgical oncology in companion animals.
Surgery remains one of the primary treatment in most cancer patients. It permits the cure when the tumor is localized and non-metastatic, but it can also be included in a multimodal approach for high-aggressive and metastatized neoplasm. In this optic, the oncologic surgeon should be not only an excellent technical surgeon but also a competent clinician able to evaluate the patient at 360°.
The management of a companion animal affected by a tumor can include surgical procedures in many steps, from the first biopsy to metastasectomy, and with different intents, from curative to palliative. Surgery can be a therapeutic procedure influencing the prognosis, but also a diagnostic tool for a correct oncological staging. The purpose of this special issue is to collect studies focused on new surgical techniques and approaches, as well as studies revealing the prognostic impact of surgery in the management of companion animals with cancer. Research articles, case report, case series and original reviews are invited to this Special Issue.

Dr. Roberta Ferrari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Surgery
  • Prognosis
  • Recurrence
  • Metastasis
  • Staging
  • Survival
  • Surgical complication

Published Papers (4 papers)

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Research

13 pages, 1757 KiB  
Article
Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery
by Marina Martano, Paolo Buracco and Emanuela Maria Morello
Animals 2021, 11(12), 3444; https://doi.org/10.3390/ani11123444 - 2 Dec 2021
Cited by 5 | Viewed by 4570
Abstract
Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or [...] Read more.
Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies are helpful in differential diagnosis, but flow cytometry may improve the pre-operative diagnostic ability. Concurrent paraneoplastic syndromes such as myasthenia gravis and hypercalcemia have been reported; however, their role as prognostic factors is not well determined. Surgical excision is the treatment of choice; adjuvant radiotherapy and/or chemotherapy may prolong survival in cases of incomplete excision or when a thymic carcinoma is diagnosed. Local recurrence and metastasis are infrequently reported; therefore, a long survival time is expected if the tumor is completely excised or if adjuvant therapy is undertaken. This article reports the authors’ experience with 28 dogs affected by 18 thymomas and 10 thymic carcinomas. The median overall survival in this series was 1173 days, and the median disease-free interval was 903 days. Dogs with thymic carcinoma had significantly shorter disease-free intervals and shorter, although not statistically significant, survival times. Dogs with Masaoka Stage III tumors had worse outcomes. Full article
(This article belongs to the Special Issue Surgical Oncology in Companion Animals)
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13 pages, 2168 KiB  
Article
Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?
by Roberta Ferrari, Patrizia Boracchi, Lavinia Elena Chiti, Martina Manfredi, Chiara Giudice, Donatella De Zani, Carlotta Spediacci, Camilla Recordati, Valeria Grieco, Elisa Maria Gariboldi and Damiano Stefanello
Animals 2021, 11(8), 2373; https://doi.org/10.3390/ani11082373 - 11 Aug 2021
Cited by 21 | Viewed by 3414
Abstract
The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. [...] Read more.
The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. The study aimed to assess the association between clinicopathological variables and SLN status, determining the identification of dogs at lower risk of SLN metastases. Dogs with integumentary MCT were admitted to the lymphoscintigraphic mapping and subsequent biopsy of SLN. The association between clinicopathological variables of MCT and SLN status was statistically tested, both considering occult and overt metastasis together (HN2-HN3) and overt metastasis (HN3) alone. Fifty low-grade cutaneous MCT and 16 subcutaneous MCT were included. A small to moderate association between integumentary MCT ≥ 3 cm and HN2-HN3 SLN was found. A strong association of integumentary MCT dimension and subcutaneous MCT with HN3 SLN occurred. Dimension of low-grade cutaneous and subcutaneous MCT seems to correlate with SLN status, but additional study should confirm this data before excluding small MCT to the SLN biopsy. On the contrary, the study results induce a solid suggestion for mapping and biopsy of the SLN in MCT > 3 cm and subcutaneous MCT. Full article
(This article belongs to the Special Issue Surgical Oncology in Companion Animals)
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12 pages, 4633 KiB  
Article
Surgical Margins in Canine Cutaneous Soft-Tissue Sarcomas: A Dichotomous Classification System Does Not Accurately Predict the Risk of Local Recurrence
by Lavinia Elena Chiti, Roberta Ferrari, Paola Roccabianca, Patrizia Boracchi, Francesco Godizzi, Giuseppe Achille Busca and Damiano Stefanello
Animals 2021, 11(8), 2367; https://doi.org/10.3390/ani11082367 - 11 Aug 2021
Cited by 8 | Viewed by 3513
Abstract
Adjuvant treatments are recommended in dogs with incompletely excised cutaneous soft-tissue sarcoma (STS) to reduce the risk of local recurrence (LR), although guidelines are lacking on how to manage clean but close margins (CbCM). This retrospective study investigates the impact of CbCM on [...] Read more.
Adjuvant treatments are recommended in dogs with incompletely excised cutaneous soft-tissue sarcoma (STS) to reduce the risk of local recurrence (LR), although guidelines are lacking on how to manage clean but close margins (CbCM). This retrospective study investigates the impact of CbCM on LR of canine STS. Ninety-eight surgically excised canine STS at first presentation were included. Tissue samples were routinely trimmed and analyzed. Cumulative incidence of LR was estimated for each category of margins (tumor-free, infiltrated, CbCM), and included CbCM in the tumor-free and infiltrated category, respectively. The prognostic impact on LR was then adjusted for relevant prognostic factors. Cumulative incidence of LR at three years differed significantly between the three categories (p = 0.016), and was estimated to be 42% with infiltrated margins, 23% with CbCM, 7% with tumor-free margins. Both when CbCM were grouped with infiltrated margins (p = 0.033; HR = 5.05), and when CbCM were grouped with tumor-free margins (p = 0.011; HR = 3.13), a significant difference between groups was found. STS excised with infiltrated margins had the greatest risk of LR. The rate of LR with CbCm was greater than recurrence rate of tumor-free margins. The category CbCM may be considered as a separate prognostic category. Full article
(This article belongs to the Special Issue Surgical Oncology in Companion Animals)
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12 pages, 1047 KiB  
Article
Benign or Low-Grade Malignant Masses Occupying the Pelvic Canal Space in 11 Dogs
by Erica Ilaria Ferraris, Davide Giacobino, Selina Iussich, Matteo Olimpo, Alberto Valazza, Marina Martano, Paolo Buracco and Emanuela Maria Morello
Animals 2021, 11(5), 1361; https://doi.org/10.3390/ani11051361 - 11 May 2021
Cited by 1 | Viewed by 4488
Abstract
Dogs with benign intra-pelvic rectal or vaginal masses show symptoms indicating compression on the adjacent organs. Clinical signs usually develop late when the lesion is large enough to interfere functionally. The dogs were referred for severe fecal and/or urinary tenesmus. The data collected [...] Read more.
Dogs with benign intra-pelvic rectal or vaginal masses show symptoms indicating compression on the adjacent organs. Clinical signs usually develop late when the lesion is large enough to interfere functionally. The dogs were referred for severe fecal and/or urinary tenesmus. The data collected included signalment, clinical signs, results of physical examination, pre-surgical diagnostic tests, surgical technique used, surgical complications and histological findings. Digital rectal and vaginal examination allowed the detection of a mass occupying space in the pelvic cavity in all patients. Abdominal ultrasonography and/or total body computed tomography (CT) were used to better characterize the lesion and to exclude a metastatic spread of the tumor in case of malignancy. A dorsal approach to the rectum, a dorsal episiotomy, a midline celiotomy, and a combined perineal and abdominal approach were performed to remove the mass. No postoperative complications were observed. Benign and well-differentiated malignant mesenchymal neoplasms were histologically diagnosed. As a consequence of the chronic urethral compression caused by the mass, urinary incontinence and/or urinary retention were observed for a few postoperative days. Fecal tenesmus resolved in all cases in the immediate postoperative period. The dogs’ quality of life quickly improved after surgery, especially considering the serious and life-threatening pre-surgical clinical conditions. Both the recovery time after surgery and overall survival were also evaluated. Full article
(This article belongs to the Special Issue Surgical Oncology in Companion Animals)
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