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5.2
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Journals
Animals
Special Issues
Innate Host Defence Mechanisms of Aquatic Animals
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Innate Host Defence Mechanisms of Aquatic Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 10 May 2026 | Viewed by 447

Special Issue Editor

Dr. Marcia Saraiva

E-Mail Website
Guest Editor
CIIMAR, Interdisciplinary Centre of Marine and Environmental Research of the University of Porto, Porto, Portugal
Interests: aquaculture; molecular; transcriptomics; pathogen
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increased incidence of disease, driven by environmental changes, intensive farming, and emerging pathogens, underscores the importance of understanding host responses. The innate immune system, the first line of defence against pathogens in animals, is highly influenced by environmental factors such as water temperature, salinity, and pathogen exposure. Therefore, we invite researchers to share their latest insights regarding the innate immune response of aquatic animals to pathogens, as this will enable us to develop effective countermeasures. These contributions can be in the form of reviews, opinion articles, or original multidisciplinary research.

Dr. Marcia Saraiva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunology
  • virus
  • bacteria
  • fungus
  • fungus-like

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Published Papers (1 paper)

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Research

18 pages, 2966 KB  
Article
Comparative Transcriptomic Analysis of the Liver and Spleen in Ussuri Catfish (Pseudobagrus ussuriensis) Challenged with Polyriboinosinic Polyribocytidylic Acid (Poly(I:C))
by Yu Liu, Ke Wang, Lingyun Lu, Huanhuan Miao, Libo Gu, Zhipeng Dou and Qing Liu
Animals 2025, 15(16), 2454; https://doi.org/10.3390/ani15162454 - 21 Aug 2025
Viewed by 145
Abstract
Poly (I:C), a viral mimic, is capable of activating the antiviral immune mechanisms in teleosts. In this study, we investigated the transcriptional responses of Ussuri Catfish (Pseudobagrus ussuriensis) to poly (I:C) stimulation at 3 and 48 h, focusing on the similarities [...] Read more.
Poly (I:C), a viral mimic, is capable of activating the antiviral immune mechanisms in teleosts. In this study, we investigated the transcriptional responses of Ussuri Catfish (Pseudobagrus ussuriensis) to poly (I:C) stimulation at 3 and 48 h, focusing on the similarities and differences in antiviral mechanisms exhibited in the liver and spleen. At 3 h, the signaling pathways that were concurrently enriched in both the spleen and liver include JAK-STAT, TNF, NF-κB, RIG-I-like receptor, and NOD-like receptor. At 48 h, the signaling pathways that were concurrently enriched in both the spleen and liver include JAK-STAT signaling and cellular homeostasis processes. However, in the liver, the signaling pathways that responded to poly (I:C) stimulation at both 3 and 48 h are cytokine–cytokine receptor interaction and RIG-I-like receptor signaling. In the spleen, the signaling pathways that responded to poly (I:C) stimulation at both 3 and 48 h are Hippo signaling, Wnt signaling, TGF-β signaling, and ECM-receptor interaction. Ultimately, the pathways that were enriched in the intersection genes across all groups are JAK-STAT signaling, NK cell-mediated cytotoxicity, and ECM-receptor interaction, and the core genes identified in the intersection genes of all groups are PTPRS, HECW1, and ERN1 (IRE1), along with UMAD, DKK1, CSH, and RTKN2. Through this study, we identified the key signaling pathways and core genes involved in the antiviral response of Ussuri catfish. These findings provide valuable insights into the antiviral mechanisms of Ussuri catfish. Full article
(This article belongs to the Special Issue Innate Host Defence Mechanisms of Aquatic Animals)
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