Nanotoxicology - Current State and Development Prospects

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 14661

Special Issue Editors


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Guest Editor
Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland

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Guest Editor
Departament of Ichthyology and Biotechnology in Aquaculture, Institute of Animal Sciences, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland

Special Issue Information

Dear Colleagues,

Currently, the nanobiotechnology and nanoproducts industry is developing very dynamically. At the same time, the awareness of their total impact on living organisms is still insufficient. The accumulation of nanoparticles in various organs, including the liver or brain, has been repeatedly confirmed.  

Nanoparticles occur in both aquatic and terrestrial environments. They can be artificially produced and derived from anthropogenic materials as a result of degradation. The potential for contamination of their environment comes at different stages of product consumption, and due to their size, they can penetrate the organisms of animals in many ways. 

It is crucial to determine the impact of nanoparticles on functioning ecosystems, and particularly important to assess the dynamics of physicochemical changes of nanoxenobiotics in changing environmental conditions, as well as their impact on living organisms and functioning trophic connections. 

Therefore, it seems necessary to support further research on the properties and influence of nanoparticles on the organisms of animals, as well as research aimed at selecting the best animal models for nanoparticle research in various fields. Such studies will support the effective estimation of the toxicity of nanoproducts in the natural environment and the development of nanoecotoxicology. 

The subject of this Special Issue, therefore, covers the broadly understood use and impact of nanoparticles on animal organisms and the functioning of ecosystems.

Dr. Maciej Wojcik
Prof. Maciej Kamaszewski
Guest Editors

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Keywords

  • nanoparticles
  • nanoproducts
  • nanoecotoxicology
  • physiology
  • animal model
  • markers of nanoparticle toxicity

Published Papers (4 papers)

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Research

12 pages, 2380 KiB  
Article
Toxicity of Zinc Oxide Nanoparticles on the Embryo of Javanese Medaka (Oryzias javanicus Bleeker, 1854): A Comparative Study
by Naweedullah Amin, Syaizwan Zahmir Zulkifli, Mohammad Noor Amal Azmai and Ahmad Ismail
Animals 2021, 11(8), 2170; https://doi.org/10.3390/ani11082170 - 22 Jul 2021
Cited by 9 | Viewed by 3626
Abstract
(1) Background: Zinc oxide nanoparticles (ZnO NPs) are widely applied in various human products. However, they can be extremely toxic for aquatic organisms, particularly fish. This research was conducted to determine the LC50 of ZnO NPs on the embryos of Javanese medaka [...] Read more.
(1) Background: Zinc oxide nanoparticles (ZnO NPs) are widely applied in various human products. However, they can be extremely toxic for aquatic organisms, particularly fish. This research was conducted to determine the LC50 of ZnO NPs on the embryos of Javanese medaka (Oryzias javanicus) in ultra-pure, deionized, and dechlorinated tap water; (2) Methods: The experiments were conducted in a completely randomized design (CRD) with three replicates for six treatments for acute (0.100, 0.250, 0.500, 1.00, 5.00, and 10.00 mg/L) exposures for each type of water; (3) Results: The LC50 of ZnO NPs at 96 h was determined as 0.643 mg/L in ultra-pure water, 1.333 mg/L in deionized water, and 2.370 in dechlorinated tap water. In addition to concentration-dependent toxicity, we also observed time-dependent toxicity for ZnO NPs. In addition, the sizes of ZnO NPs increased immediately after dispersion and were 1079 nm, 3209 nm, and 3652 nm in ultra-pure, deionized, and dechlorinated tap water. The highest concentration of measured Zn2+ in exposure concentrations was found in ultra-pure water, followed by deionized and dechlorinated tap water suspensions. Furthermore, Javanese medaka showed high sensitivity to acute exposure of ZnO NPs in all types of water. Full article
(This article belongs to the Special Issue Nanotoxicology - Current State and Development Prospects)
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13 pages, 12363 KiB  
Article
Impact of Ag Nanoparticles (AgNPs) and Multimicrobial Preparation (EM) on the Carcass, Mineral, and Fatty Acid Composition of Cornu aspersum aspersum Snails
by Tomasz Niemiec, Andrzej Łozicki, Robert Pietrasik, Sylwester Pawęta, Anna Rygało-Galewska, Magdalena Matusiewicz and Klara Zglińska
Animals 2021, 11(7), 1926; https://doi.org/10.3390/ani11071926 - 28 Jun 2021
Cited by 8 | Viewed by 2164
Abstract
The hygienic practices on farms should reduce pathogenic microorganisms while simultaneously not harming the animals themselves; they must also not degrade the products’ quality. We assessed the effect of covering feed tables with paint containing silver nanoparticles (AgNPs) and the periodic spraying of [...] Read more.
The hygienic practices on farms should reduce pathogenic microorganisms while simultaneously not harming the animals themselves; they must also not degrade the products’ quality. We assessed the effect of covering feed tables with paint containing silver nanoparticles (AgNPs) and the periodic spraying of effective microorganisms (EM) on production indicators and basic chemical composition, mineral content and fatty acid profiles in the bodies of Cornu aspersum aspersum snails. The animals were divided into four groups: (1) control, (2) with feed tables covered with AgNPs paint, (3) with EM spray applied and (4) with both factors—AgNP paint and EM spray. The highest increase in Ag, Zn, Fe and Ca retention, and the remodelling of the fatty acid profile in the carcasses of snails was found to be in the group of animals in contact with the feed tables covered with AgNP paint. In the group of animals exposed to the action of EM, an increased retention of Fe, Cu, P, Mg and Zn was found. Full article
(This article belongs to the Special Issue Nanotoxicology - Current State and Development Prospects)
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11 pages, 917 KiB  
Article
Effects of Silver Nanoparticles on Proliferation and Apoptosis in Granulosa Cells of Chicken Preovulatory Follicles: An In Vitro Study
by Dorota Katarzyńska-Banasik, Anna Kozubek, Małgorzata Grzesiak and Andrzej Sechman
Animals 2021, 11(6), 1652; https://doi.org/10.3390/ani11061652 - 2 Jun 2021
Cited by 2 | Viewed by 3718
Abstract
The continuous development of poultry production related to the growing demand for eggs and chicken meat makes it necessary to use modern technologies. An answer to this demand may be the use of nanotechnology in poultry farming. One of the promising nanomaterials in [...] Read more.
The continuous development of poultry production related to the growing demand for eggs and chicken meat makes it necessary to use modern technologies. An answer to this demand may be the use of nanotechnology in poultry farming. One of the promising nanomaterials in this field are silver nanoparticles (AgNPs), which are used as disinfectants, reducing microbial pollution and the amounts of greenhouse gases released. This study aimed to evaluate the effect of AgNPs on the proliferation and apoptosis process in the granulosa cells of chicken preovulatory follicles. The in vitro culture experiment revealed that both 13 nm and 50 nm AgNPs inhibited the proliferation of the granulosa cells. However, a faster action was observed in 50 nm AgNPs than in 13 nm ones. A size-dependent effect of AgNP was also demonstrated for the caspase-3 activity. AgNPs 13 nm in size increased the caspase-3 activity in granulosa cells, while 50 nm AgNPs did not exert an effect, which may indicate the induction of distinct cell death pathways by AgNPs. In conclusion, our study reveals that AgNPs in vitro inhibit granulosa cell proliferation and stimulate their apoptosis. These results suggest that AgNPs may disrupt the final stage of preovulatory follicle maturation and ovulation. Full article
(This article belongs to the Special Issue Nanotoxicology - Current State and Development Prospects)
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22 pages, 3775 KiB  
Article
Calcium Carbonate Nanoparticles—Toxicity and Effect of In Ovo Inoculation on Chicken Embryo Development, Broiler Performance and Bone Status
by Arkadiusz Matuszewski, Monika Łukasiewicz, Jan Niemiec, Maciej Kamaszewski, Sławomir Jaworski, Małgorzata Domino, Tomasz Jasiński, André Chwalibog and Ewa Sawosz
Animals 2021, 11(4), 932; https://doi.org/10.3390/ani11040932 - 25 Mar 2021
Cited by 6 | Viewed by 3647
Abstract
The use of intensive selection procedure in modern broiler chicken lines has led to the development of several skeletal disorders in broiler chickens. Therefore, current research is focused on methods to improve the bone quality in birds. In ovo technology, using nanoparticles with [...] Read more.
The use of intensive selection procedure in modern broiler chicken lines has led to the development of several skeletal disorders in broiler chickens. Therefore, current research is focused on methods to improve the bone quality in birds. In ovo technology, using nanoparticles with a high specificity to bones, is a potential approach. The present study aimed to evaluate the effect of in ovo inoculation (IOI) of calcium carbonate nanoparticles (CCN) on chicken embryo development, health status, bone characteristics, and on broiler production results and bone quality. After assessing in vitro cell viability, the IOI procedure was performed with an injection of 500 μg/mL CCN. The control group was not inoculated with CCN. Hatchability, weight, and selected bone and serum parameters were measured in embryos. Part of hatchlings were reared under standard conditions until 42 days, and production results, meat quality, and bone quality of broilers were determined. CCN did not show cytotoxicity to cells and chicken embryo and positively influenced bone parameters of the embryos and of broilers later (calcification) without negatively affecting the production results. Thus, the IOI of CCN could modify the molecular responses at the stage of embryogenesis, resulting in better mineralization, and could provide a sustained effect, thereby improving bone quality in adult birds. Full article
(This article belongs to the Special Issue Nanotoxicology - Current State and Development Prospects)
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