Nutritional Regulation of Gut Microbiota in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: 25 December 2026 | Viewed by 528

Special Issue Editors

College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
Interests: gut microbiota; nutritional regulation; microbe-metabolite-host interactions
College of Animal Science and Technology, Northwest A&F University, Xianyang, China
Interests: microbiome; rumen; intestinal health

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Guest Editor
State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing 100193, China
Interests: gut microbiota; amino acids; animal nutrition; reproduction

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Nutritional Regulation of Gut Microbiota in Animals,” focuses on how diet or feed additives shape microbial communities and microbe–metabolite–host interactions that influence growth, health, welfare, and sustainability across animal species. Its scope spans domestic livestock, Cervids and other special economic animals, companion animals, experimental animals and wildlife under managed care. We welcome original research, reviews, and methodological papers discussing controlled feeding trials; multi-omics (metagenomics, metabolomics, transcriptomics), gnotobiotic or probiotic/prebiotic/postbiotic interventions; modeling of fermentation and VFA/bile-acid pathways; and translational studies linking mechanisms to performance or clinical outcomes. This Special Issue’s goal is to move beyond correlation toward causal, mechanism-based nutrition that can be implemented in practice.

This Special Issue will complement the existing literature by (i) integrating scattered findings across species and diets into a comparative framework, (ii) pairing nutritional manipulations with rigorous multi-omics to define actionable levers, and (iii) encouraging harmonized reporting, data sharing, and replication to improve reproducibility and uptake in the field.

Dr. Huazhe Si
Dr. Shengru Wu
Dr. Ning Liu
Guest Editors

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Keywords

  • gut microbiota
  • nutritional regulation
  • microbe–metabolite–host interactions
  • short-chain fatty acids
  • bile acids
  • probiotics/prebiotics/postbiotics
  • multi-omics

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Published Papers (1 paper)

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Research

20 pages, 2073 KB  
Article
Rumen-Protected Methionine Supplementation in the Diet Improved the Production Performance of Dairy Goats by Optimizing the Amino Acid Profile and Lipid Metabolism and Modulating the Colonic Microbiome
by Xingwei Jiang, Jiarui Wang, Yuhao Zhang, Jing Li, Huifeng Liu, Shengru Wu and Junhu Yao
Animals 2025, 15(23), 3386; https://doi.org/10.3390/ani15233386 - 24 Nov 2025
Viewed by 349
Abstract
This study aimed to investigate the effects of rumen-protected methionine (RPM) on the production performance of lactating dairy goats. Thirty first-time lactating Guanzhong dairy goats with identical kidding dates and comparable body weights (41.17 ± 3.05 kg) were randomly assigned to two groups: [...] Read more.
This study aimed to investigate the effects of rumen-protected methionine (RPM) on the production performance of lactating dairy goats. Thirty first-time lactating Guanzhong dairy goats with identical kidding dates and comparable body weights (41.17 ± 3.05 kg) were randomly assigned to two groups: (1) CON: basal diet and (2) RPM: basal diet + 7.5 g/day RPM. The duration of the experiment was 21 days. Compared with the CON group, the RPM group presented a significant increase in milk yield, 4% fat-corrected milk (FCM), and feed efficiency; however, no significant difference was observed in dry feed intake (DMI). Moreover, milk fat, protein, lactose, and SNF production was greater in the PRM group than in the CON group. Compared with the CON group, the RPM group presented higher nonesterified fatty acid (NEFA) and very-low-density lipoprotein (VLDL) levels, and no significant differences in the other metabolites were detected. The concentrations of acetate, propionate, and total volatile fatty acids (TVFAs) in the feces of the RPM group were significantly greater than those in the CON group; however, no significant differences were detected in the concentrations of isobutyrate, butyrate, and valerate. Furthermore, genera such as Muribaculaceae, Bifidobacterium, and Christensenellaceae were significantly enriched in the feces of the RPM group. Concurrently, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the RPM group was significantly enriched in pathways associated with amino acid synthesis, the immune system, and energy metabolism. In summary, dietary supplementation with RPM improved the lipid metabolism function of the liver, increased the abundance of beneficial bacteria such as Muribaculaceae and Bifidobacterium in the colon, and enriched microbial functions related to energy and amino acid metabolism, thereby enhancing colon fermentation and host metabolic status, ultimately improving the production performance of lactating dairy goats. These findings elucidate the positive effects of RPM on the production performance and metabolic health of dairy goats, potentially offering new perspectives and strategies for optimizing dairy production. Full article
(This article belongs to the Special Issue Nutritional Regulation of Gut Microbiota in Animals)
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