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Advances in Feed Additives for Enhancing Early Lactation Performance in Ruminants

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 854

Special Issue Editor

College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Interests: cattle; feed additives; immunity; early lactation; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The early lactation period is a crucial stage in ruminants, characterized by metabolic imbalances, immunosuppression, and variable milk production, all of which compromise health and productivity. Historically, antibiotics were routinely used in early lactation for pathogen control and inflammation management. However, given the risks of antimicrobial resistance and food safety, replacing antibiotics with feed additives has emerged as a dominant approach in livestock production. The proper utilization of nutritional additives helps to optimize energy and metabolism, boost immune function, and maintain intestinal health.

This Special Issue aims to highlight the role of feed additives in the early lactation period, investigating their mechanisms and impacts on ruminant health, metabolism, and milk production. By bridging research and practice, this Special Issue will support evidence-based strategies for sustainable ruminant production.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Nutritional regulation and metabolic improvements;
  • Immunomodulation and stress resistance;
  • Rumen health and fermentation enhancement;
  • Molecular mechanisms of lactation performance;
  • Antibiotic alternatives;
  • Sustainability and environmental impacts.

We look forward to receiving your contributions.

Dr. Kang Zhan
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrients
  • ruminants
  • feed additives
  • early lactation
  • immunity
  • metabolism
  • rumen

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Published Papers (1 paper)

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Research

14 pages, 935 KB  
Article
Metagenomic Insights into the Modulatory Effects of Thiamine Supplementation for Treating Subclinical Ketosis Dairy Cows
by Fuguang Xue, Fan Zhang, Qinghao Zhuang, Ling Jiang, Mengjie Sun, Jinliang Shang and Benhai Xiong
Animals 2026, 16(4), 680; https://doi.org/10.3390/ani16040680 - 21 Feb 2026
Viewed by 462
Abstract
(1) Background: The objective of this study was to investigate the modulatory effects of thiamine on BHBA metabolism, milk yield, and the rumen microbial ecosystem. (2) Methods: A total of 24 SCK dairy cows with similar body conditions were selected and randomly allocated [...] Read more.
(1) Background: The objective of this study was to investigate the modulatory effects of thiamine on BHBA metabolism, milk yield, and the rumen microbial ecosystem. (2) Methods: A total of 24 SCK dairy cows with similar body conditions were selected and randomly allocated to SCK (SCK) or SCK with thiamine supplement (SCKT) treatment. Twelve healthy dairy cows served as the control (CON) treatment. Milk yield, milk quality, ruminal fermentability parameters, rumen and fecal microbial communities were further measured. (3) Results: Thiamine significantly decreased BHBA content, milk CFUs, and somatic cells, while significantly increasing milk yield, milk fat, acetate, and the A/P ratio (p < 0.05). Thiamine-treated cows exhibited significantly increased ruminal and fecal Proteobacteria but significantly decreased ruminal Firmicutes (p < 0.05) as well as fecal Spirochaetes and Cyanobacteria (p < 0.05), compared with SCK cows. Functional analysis showed that differential rumen bacteria exhibited high energy metabolism, nucleotide metabolism, and glycan biosynthesis and metabolism, while the metabolism of terpenoids and polyketides were the primary functional pathways of differential fecal microbiota. (4) Conclusions: Thiamine supplementation in SCK cows effectively alleviated subclinical ketosis by reducing BHBA content, enhancing ruminal fermentability, and proliferating rumen microbial communities, leading to improved milk yield in the early-lactation period. Full article
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