Feed Additives and Micronutrients on Performance, Nutrient Utilization, Immunity, Oxidative Stress, Gut Health and Microbiome of Pigs and Sows: Third Edition

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Pigs".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 181

Special Issue Editor


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Guest Editor
College of Agricultural & Environmental Sciences, University of Georgia, Athens, GA, USA
Interests: enzymes; butyrate; emulsifier; probiotics; prebiotics; postbiotics; antioxidants; minerals; vitamins; sows; weaning pigs; growing-finishing pigs
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Special Issue Information

Dear Colleagues,

In modern swine production, weaning pigs and sows face several challenges, including stress, disease, nutritional deficiencies, and gut-related issues. Nutrition, particularly the inclusion of functional amino acids, micronutrients, and feed additives, plays a key role in supporting growth, immune function, gut health, and overall resilience. Sows are essential to swine productivity, and their reproductive performance, colostrum and milk quality, and maternal gut microbiome directly affect the survival, development, and immunity of their piglets.

Studies have shown that both traditional and novel feed additives, along with functional amino acids, vitamins, and minerals, can enhance nutrient utilization, immunity, antioxidant capacity, gut integrity, microbial balance, and intestinal barrier function. These benefits are especially important during vulnerable periods, such as weaning, when piglets are prone to stress, oxidative damage, and gut permeability, and farrowing, when sows experience significant physiological stress.

However, further research is required to determine the optimal levels and specific functions of these nutrients and additives, as well as to better understand their mechanisms of action.

This Special Issue invites original research and review articles focused on the roles of feed additives, functional amino acids, and micronutrients in enhancing performance, immunity, resistance to oxidative stress, gut microbiota, and intestinal health in pigs and sows. The aim is to support sustainable, health-focused swine production through science-based nutritional strategies.

Dr. Young-Dal Jang
Guest Editor

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Keywords

  • weaning pigs
  • gut health
  • amino acids
  • vitamins
  • minerals
  • feed additives
  • sows
  • immunity
  • digestibility
  • microbiome

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Published Papers (1 paper)

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Research

20 pages, 3163 KiB  
Article
Walnut Green Husk Extract Enhances Antioxidant, Anti-Inflammatory, and Immune Functions by Regulating Gut Microbiota and Metabolites in Fattening Pigs
by Jing Wang, Mingyang Jia, Qi Zhang, Xiangzhou Yan, Yaping Guo, Lei Wang and Baosong Xing
Animals 2025, 15(16), 2395; https://doi.org/10.3390/ani15162395 - 15 Aug 2025
Abstract
This study investigates the effect of walnut green husk extract (WE) on gut microbiota, metabolites, and immune-antioxidant changes in fattening pigs through gut microbiota-metabolite interactions. A total of 60 healthy fattening pigs (Duroc × Landrace × Yorkshire) with an initial body weight of [...] Read more.
This study investigates the effect of walnut green husk extract (WE) on gut microbiota, metabolites, and immune-antioxidant changes in fattening pigs through gut microbiota-metabolite interactions. A total of 60 healthy fattening pigs (Duroc × Landrace × Yorkshire) with an initial body weight of 65.2 ± 3.1 kg were randomly assigned to two groups (n = 30 per group): the control group (NC), which was fed a basal diet, and the WE group, which was fed the basal diet supplemented with 0.1% walnut green husk extract (WE). Dietary supplementation with 0.1% WE significantly increased the relative abundances of beneficial bacteria (e.g., Firmicutes, Lactobacillus) and reduced pathogenic bacteria (e.g., Proteobacteria, Shigella). Untargeted metabolomics identified 170 differentially accumulated metabolites, among which propionic acid—a key short-chain fatty acid with immunomodulatory effects—was significantly upregulated by 1.09-fold (p = 0.03) and showed a positive correlation with beneficial microbial abundances. These metabolites were enriched in glycerophospholipid and α-linolenic acid metabolism pathways, where eicosadienoic acid inhibited the nuclear factor kappa-B (NF-κB) pathway for anti-inflammatory effects, and methyl cinnamate synergistically regulated mitogen-activated protein kinase (MAPK) signaling with Lactobacillus. Serum analyses showed that WE significantly enhanced IgA, IgM, and IgG levels by 3.97-fold, 4.67-fold, and 4.43-fold (p < 0.01), reduced malondialdehyde (MDA) concentration by 82.8% (p < 0.01), and trended to improve antioxidant capacity via glutamine. Mechanistically, WE promoted short-chain fatty acid production by beneficial bacteria, forming a “microbiota–metabolite–immunity” cascade to enhance lipid metabolism and alleviate intestinal inflammation. These findings highlight that WE provides multi-omics evidence for its application as a functional feed additive. Full article
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