Fruit Allergies, New Emerging Allergens

A special issue of Allergies (ISSN 2313-5786). This special issue belongs to the section "Food Allergy".

Deadline for manuscript submissions: closed (18 December 2022) | Viewed by 5406

Special Issue Editor

Guest Editor
Institut de Recherche et Développement, Faculté de Pharmacie, UMR 152 PharmaDev, Université Paul Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, France
Interests: food allergy; allergens; epitopes; celiac disease; structural approaches
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Special Issue Information

Dear Colleagues,

The increasing consumption of fruits, often from tropical/sub-tropical countries, has given rise to food allergic responses with diverse outcomes depending on the people, from a simple oral syndrome up to severe anaphylactic responses. In addition, seeds occurring in fruits are an important source of allergens that essentially correspond to the potentially dangerous seed storage 2S albumins and 7S or 11S globulins. The main families of fruit and vegetable allergens have been characterized as lipid transfer proteins (LTP), thaumatin-like proteins (TLP), and various allergens with enzymatic properties (chitinases, glucanases, proteases). Moreover, fruits and vegetable contain profilins and PR10 Bet v 1-like proteins that are associated to the pollen-food allergy syndrome of fruits from the Rosaceae and Cupressaceae. Moreover, an increasing number of newly characterized allergens from fruit are proposed every year.

This Special Issue is aimed at: 1) making an inventory, as exhaustive as possible, of the different families of fruit allergens, including seed allergens from fruits; 2) reporting their main structural and physico-chemical characteristics; 3) illustrating their implication in anaphylactic reactions; 4) reporting the main IgE-binding cross reactivities and, eventually, the crossed allergic reactions, they can cause. New emerging fruit allergens should be emphasized. 

The study of fruit allergens should benefit from the progress made in the fields of  genome sequencing (multiplicity of allergens expressed in fruits, allergen isoforms, new allergens) and ligand-allergen interactions (effects of small ligand molecules on the allergenicity of fruit, e.g., LTP, and relationship between food allergy and innate immunity). 

Both Review and Articles are solicited, dealing with all aspects of fruit allergies and allergens, which include: 

  • Overview of edible fruits;
  • Structural and physico-chemical properties of the main families of fruit allergens, including seed allergens from fruits;
  • Allergen repertoire of the currently consumed fruits;
  • Emerging fruit allergens/allergies;
  • Fruit allergens as causative agents of IgE-binding cross reactivities and/or crossed allergies;
  • Diagnosis and treatment of fruit allergies.

Prof. Dr. Pierre Rougé
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Allergies is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • allergen
  • chitinase
  • cupin
  • fruit allergy
  • gibberellin-related proteins
  • innate immunity
  • latex-fruit syndrome
  • lipid transfer protein
  • pollen-food allergy syndrome
  • PR5 Thaumatin-like protein
  • PR10 Bet v 1-like protein
  • profilin
  • glucanase
  • peptidase
  • peroxydase
  • polygalacturonase

Published Papers (1 paper)

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14 pages, 1911 KiB  
Systematic Review
Seed Storage Protein, Functional Diversity and Association with Allergy
by Abha Jain
Allergies 2023, 3(1), 25-38; - 18 Jan 2023
Cited by 7 | Viewed by 4345
Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and more. The major elements that are utilized for our needs exist in storage organs, such as seeds. These seeds are rich in proteins, show a broad [...] Read more.
Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and more. The major elements that are utilized for our needs exist in storage organs, such as seeds. These seeds are rich in proteins, show a broad spectrum of physiological roles, and are classified based on their sequence, structure, and conserved motifs. With the improvements to our knowledge of the basic sequence and our structural understanding, we have acquired better insights into seed proteins and their role. However, we still lack a systematic analysis towards understanding the functional diversity associated within each family and their associations with allergy. This review puts together the information about seed proteins, their classification, and diverse functional roles along with their associations with allergy. Full article
(This article belongs to the Special Issue Fruit Allergies, New Emerging Allergens)
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