The “Systems Neuroscience” Section is dedicated to the research and exploration of multifactorial and multidimensional processes, such as normal and pathological aspects of sensory and motor functions; the activity of limbic and cognitive systems; and cerebral control of homeostasis, locomotion, reproduction, etc. By building a bridge between various theoretical concepts, basic science research, and clinical medicine applications, the “Systems Neuroscience” Section of the journal provides an in-depth analysis of the intricate workings of the nervous system. The focus of this Section goes beyond isolated aspects of neuroscience research and dedicates itself to a more comprehensive view of neural mechanisms and functionality.

As all of the articles published in our journal are of an open access format, you have free and unlimited access to the full texts. We welcome you to read our most highly cited papers published in 2022 and 2023 listed below.

1. “Innovative Technologies in the Neurorehabilitation of Traumatic Brain Injury: A Systematic Review”
by Mirjam Bonanno, Rosaria De Luca, Alessandro Marco De Nunzio, Angelo Quartarone and Rocco Salvatore Calabrò
Brain Sci. 2022, 12(12), 1678; https://doi.org/10.3390/brainsci12121678
Available online: https://www.mdpi.com/2076-3425/12/12/1678

2. “Serum Mature BDNF Level Is Associated with Remission Following ECT in Treatment-Resistant Depression”
by Marion Psomiades, Marine Mondino, Filipe Galvão, Nathalie Mandairon, Mikail Nourredine, Marie-Françoise Suaud-Chagny and Jérôme Brunelin
Brain Sci. 2022, 12(2), 126; https://doi.org/10.3390/brainsci12020126
Available online: https://www.mdpi.com/2076-3425/12/2/126

3. “Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction”
by Hui Zhang, Tom Wai-Hin Chung, Fergus Kai-Chuen Wong, Ivan Fan-Ngai Hung and Henry Ka-Fung Mak
Brain Sci. 2022, 12(4), 511; https://doi.org/10.3390/brainsci12040511
Available online: https://www.mdpi.com/2076-3425/12/4/511

4. “It Takes Two: Interpersonal Neural Synchrony Is Increased after Musical Interaction”
by Alexander Khalil, Gabriella Musacchia and John Rehner Iversen
Brain Sci. 2022, 12(3), 409; https://doi.org/10.3390/brainsci12030409
Available online: https://www.mdpi.com/2076-3425/12/3/409

5. “Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review”
by Bas Labree, Derek J. Hoare, Lauren E. Gascoyne, Polly Scutt, Cinzia Del Giovane and Magdalena Sereda
Brain Sci. 2022, 12(4), 484; https://doi.org/10.3390/brainsci12040484
Available online: https://www.mdpi.com/2076-3425/12/4/484

6. “Neurological Prognostic Factors in Hospitalized Patients with COVID-19”
by Leszek Drabik, Justyna Derbisz, Zaneta Chatys-Bogacka, Iwona Mazurkiewicz, Katarzyna Sawczynska, Tomasz Kesek, Jacek Czepiel, Pawel Wrona, Joanna Szaleniec, Malgorzata Wojcik-Bugajska et al.
Brain Sci. 2022, 12(2), 193; https://doi.org/10.3390/brainsci12020193
Available online: https://www.mdpi.com/2076-3425/12/2/193

7. “Using Inhibitory DREADDs to Silence LC Neurons in Monkeys”
by Pauline Perez, Estelle Chavret-Reculon, Philippe Ravassard and Sebastien Bouret
Brain Sci. 2022, 12(2), 206; https://doi.org/10.3390/brainsci12020206
Available online: https://www.mdpi.com/2076-3425/12/2/206

8. “Dopamine Function and Hypothalamic-Pituitary-Thyroid Axis Activity in Major Depressed Patients with Suicidal Behavior”
by Fabrice Duval, Marie-Claude Mokrani, Vlad Danila, Alexis Erb, Felix Gonzalez Lopera and Mihaela Tomsa
Brain Sci. 2022, 12(5), 621; https://doi.org/10.3390/brainsci12050621
Available online: https://www.mdpi.com/2076-3425/12/5/621

9. “Effects of Aerobic Training on Brain Plasticity in Patients with Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials”
by Farid Farhani, Shahnaz Shahrbanian, Mohammad Auais, Amir Hossein Ahmadi Hekmatikar and Katsuhiko Suzuki
Brain Sci. 2022, 12(6), 732; https://doi.org/10.3390/brainsci12060732
Available online: https://www.mdpi.com/2076-3425/12/6/732

10. “Optimized Deep Brain Stimulation Surgery to Avoid Vascular Damage: A Single-Center Retrospective Analysis of Path Planning for Various Deep Targets by MRI Image Fusion”
by Xin Wang, Nan Li, Jiaming Li, Huijuan Kou, Jing Wang, Jiangpeng Jing, Mingming Su, Yang Li, Liang Qu and Xuelian Wang
Brain Sci. 2022, 12(8), 967; https://doi.org/10.3390/brainsci12080967
Available online: https://www.mdpi.com/2076-3425/12/8/967

11. “Sleep in Disorders of Consciousness: A Brief Overview on a Still under Investigated Issue”
by Loredana Raciti, Gianfranco Raciti, David Militi, Paolo Tonin, Angelo Quartarone and Rocco Salvatore Calabrò
Brain Sci. 2023, 13(2), 275; https://doi.org/10.3390/brainsci13020275
Available online: https://www.mdpi.com/2076-3425/13/2/275

12. “Multi-Frequency Electrocochleography and Electrode Scan to Identify Electrode Insertion Trauma during Cochlear Implantation”
by Aniket A. Saoji, Madison K. Graham, Weston J. Adkins, Kanthaiah Koka, Matthew L. Carlson, Brian A. Neff, Colin L. W. Driscoll and Douglas C. Fitzpatrick
Brain Sci. 2023, 13(2), 330; https://doi.org/10.3390/brainsci13020330
Available online: https://www.mdpi.com/2076-3425/13/2/330

13. “Sex Differences in Cognitive-Motor Dual-Task Training Effects and in Brain Processing of Semi-Elite Basketball Players”
by Stefania Lucia, Merve Aydin and Francesco Di Russo
Brain Sci. 2023, 13(3), 443; https://doi.org/10.3390/brainsci13030443
Available online: https://www.mdpi.com/2076-3425/13/3/443

14. “The Use of Neurofeedback in Sports Training: Systematic Review”
by Łukasz Rydzik, Wojciech Wąsacz, Tadeusz Ambroży, Norollah Javdaneh, Karolina Brydak and Marta Kopańska
Brain Sci. 2023, 13(4), 660; https://doi.org/10.3390/brainsci13040660
Available online: https://www.mdpi.com/2076-3425/13/4/660

15. “Excitatory Dorsal Lateral Prefrontal Cortex Transcranial Magnetic Stimulation Increases Social Anxiety”
by Anthony Minervini, Adriana LaVarco, Samantha Zorns, Ruth Propper, Christos Suriano and Julian Paul Keenan
Brain Sci. 2023, 13(7), 989; https://doi.org/10.3390/brainsci13070989
Available online: https://www.mdpi.com/2076-3425/13/7/989

16. “The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience”
by Alexandru Vlad Ciurea, Aurel George Mohan, Razvan-Adrian Covache-Busuioc, Horia Petre Costin and Vicentiu Mircea Saceleanu
Brain Sci. 2023, 13(7), 1005; https://doi.org/10.3390/brainsci13071005
Available online: https://www.mdpi.com/2076-3425/13/7/1005