Environmental and Earth Sciences Proceedings

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Editorial

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1 pages, 138 KB

Open AccessEditorial

Statement of Peer Review

by Natalia Garcia-Reyero and Carlos Barata

Environ. Earth Sci. Proc. 2025, 37(1), 4; https://doi.org/10.3390/eesp2025037004 - 1 Apr 2026

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Abstract

In submitting conference proceedings to Environmental and Earth Sciences Proceedings, the volume editors of the proceedings certify to the publisher that all papers published in this volume have been subjected to peer review administered by the volume editors [...] Full article

(This article belongs to the Proceedings of The 2nd International Online Conference on Toxics)

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7 pages, 861 KB

Open AccessProceeding Paper

Nanoparticle-Induced Oxidative Stress: Mechanisms and Implications for Human Health and Environmental Safety

by Newton Neogi, Kristi Priya Choudhury, Ibrahim Hossain, Sabbir Hossain and Md. Golam Sazid

Environ. Earth Sci. Proc. 2025, 37(1), 1; https://doi.org/10.3390/eesp2025037001 - 19 Nov 2025

Cited by 12 | Viewed by 2530

Abstract

Nanoparticles (NPs), which possess unique physicochemical qualities such as large surface area and reactivity, have brought about a revolution in a variety of sectors, including medicine and electronics. The growing ubiquity of these substances, on the other hand, has given rise to worries over the toxicological effects they have on human health and ecosystems. The condition known as oxidative stress, which is caused by an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defenses, is one of the key processes that contribute to the toxicity of NPs. An excessive amount of ROS may cause damage to cellular components such as lipids, proteins, and DNA, which can result in detrimental consequences such as inflammation, apoptosis, and the development of cancer. NP-induced oxidative stress is investigated in this work, which focuses on the molecular mechanisms that are responsible for it. These processes include mitochondrial dysfunction, catalytic redox cycling, and the release of metal ions from particle disintegration. On top of that, we investigate how the features of NPs, such as their size, shape, surface charge, and composition, affect their capacity to produce ROS. Additionally, the consequences of oxidative stress for both acute and chronic health effects are examined, in addition to the function that it plays in the toxicity of the environment. The use of antioxidants and alterations to the surface of NPs are two examples of mitigation measures that are discussed in this article. The findings of this study highlight the significance of gaining knowledge of the processes behind oxidative stress to ensure the safe design and deployment of NPs. Full article

(This article belongs to the Proceedings of The 2nd International Online Conference on Toxics)

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8 pages, 1233 KB

Open AccessProceeding Paper

Advancing Nanotoxicology: High-Throughput Screening for Assessing the Toxicity of Nanoparticle Mixtures

by Newton Neogi, Kristi Priya Choudhury, Sabbir Hossain, Md. Golam Sazid and Ibrahim Hossain

Environ. Earth Sci. Proc. 2025, 37(1), 2; https://doi.org/10.3390/eesp2025037002 - 3 Dec 2025

Cited by 1 | Viewed by 1735

Abstract

The widespread application of nanoparticles (NPs) in fields ranging from consumer products to industrial processes has led to increased concerns about their potential toxic effects on human health and the environment. While traditional toxicological studies often evaluate the effects of individual NPs, real-world exposure scenarios typically involve mixtures of NPs, where interactions between particles can significantly alter their toxicological profiles. This study provides an overview of overcoming this gap by possible utilization of high-throughput screening (HTS) for evaluation of the combined effects of NP mixtures under various exposure conditions. This review discusses HTS of metal oxide NPs, which have cytotoxic, genotoxic, and oxidative stress-inducing effects. Using HTS, this review describes multiple studies with multiple mixture ratios and exposure durations using human lung epithelial cells and zebrafish embryo systems. The review also describes a range of interactions, from synergistic effects, where the combined toxicity might be the sum of individual toxicities. Oxidative stress and metal ion release were key drivers of toxicity, particularly in metal oxide-dominant NP mixtures. This theoretical study highlights the importance of integrating HTS into nanotoxicology research to provide a more comprehensive understanding of the toxic behavior of NPs. Full article

(This article belongs to the Proceedings of The 2nd International Online Conference on Toxics)

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44 pages, 458 KB

Open AccessConference Report

Abstract of the 2nd International Online Conference on Toxics

by Natalia Garcia-Reyero and Carlos Barata

Environ. Earth Sci. Proc. 2025, 37(1), 3; https://doi.org/10.3390/eesp2025037003 - 28 Jan 2026

Cited by 1 | Viewed by 1849

Abstract

The 2nd International Online Conference on Toxics (IOCTO 2025) successfully showcased essential advancements across the entire spectrum of toxicology, from environmental exposure modelling to molecular mechanisms and novel ecotoxicological applications [...] Full article

(This article belongs to the Proceedings of The 2nd International Online Conference on Toxics)

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