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Physiologia, Volume 4, Issue 1 (March 2024) – 7 articles

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24 pages, 5043 KiB  
Review
Healthy Aging in Menopause: Prevention of Cognitive Decline, Depression and Dementia through Physical Exercise
by Carmen Guerrero-González, Cristina Cueto-Ureña, Vanesa Cantón-Habas, María Jesús Ramírez-Expósito and José Manuel Martínez-Martos
Physiologia 2024, 4(1), 115-138; https://doi.org/10.3390/physiologia4010007 - 7 Mar 2024
Cited by 2 | Viewed by 3072
Abstract
The aging of the global population is a significant and complex phenomenon with far-reaching implications for healthcare systems and society. By 2030, it is projected that the number of individuals over the age of 65 will increase by nearly 1 billion, largely due [...] Read more.
The aging of the global population is a significant and complex phenomenon with far-reaching implications for healthcare systems and society. By 2030, it is projected that the number of individuals over the age of 65 will increase by nearly 1 billion, largely due to advancements in healthcare and improvements in quality of life. Aging is a multifaceted process that encompasses a wide array of changes, spanning from the cellular level to the intricate physiological systems of the human body. At the central nervous system level, aging represents a major risk factor for conditions such as depression and cognitive impairment, which are likely linked to neuroinflammatory processes and can potentially lead to more severe dementias, including Alzheimer’s disease (AD). The higher prevalence of AD in women compared to men has led to speculation that the onset of menopause and associated phenomena, particularly the decline in estrogen levels, may play a role in the development of the disease. Furthermore, research has shown that physical exercise confers both physical and mental health benefits to older adults, with women potentially experiencing the greatest advantages. Understanding the multifaceted nature of aging and its implications for health will ensure that older adults receive the support and care essential for maintaining their health and quality of life. Full article
(This article belongs to the Section Exercise Physiology)
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15 pages, 5806 KiB  
Article
Decrease in Leptin Expression in the Liver after Prolonged Every-Other-Day Feeding in C57Bl/6 Male Mice
by Katarzyna Piotrowska, Maciej Tarnowski, Patrycja Tomasiak, Michał Czerewaty, Katarzyna Zgutka and Andrzej Pawlik
Physiologia 2024, 4(1), 100-114; https://doi.org/10.3390/physiologia4010006 - 17 Feb 2024
Viewed by 893
Abstract
Background: The positive effects of prolonged every-other-day (EOD) feeding include decreased body weight and prolonged life span, but also changes in liver metabolism and functions. In the present paper, our aim was to examine the expression of adiponectin (ADIPOQ), leptin, and their receptors [...] Read more.
Background: The positive effects of prolonged every-other-day (EOD) feeding include decreased body weight and prolonged life span, but also changes in liver metabolism and functions. In the present paper, our aim was to examine the expression of adiponectin (ADIPOQ), leptin, and their receptors (ADIPOR1, ADIPOR2, and LEPR) in the liver tissue of EOD-fed mice in comparison to ad libitum (AL)-treated mice. Methods: After 9 months of EOD treatment, liver tissue was harvested and prepared for analysis. RT-PCR, protein semi-quantitative estimation, and cellular immunolocalization was performed. Results: We noted a decreased expression of leptin in the liver tissue of the EOD male mice in comparison to the AL mice on the protein level. ADIPOQ receptor R1 protein expression was decreased in the liver of EOD-fed male mice, while the expression of ADIPOR2 on the protein level was increased in the EOD animals. Conclusions: To the best of our knowledge, this is the first report showing ADIPOQ and leptin immunolocalization in the liver tissue in a dietary regime experiment. Decreases in leptin expression and IL-6 expression in liver tissue and increases in ADIPOR2 expression may be partly responsible for the beneficial effects of EOD treatment in the liver, including the decrease in inflammation. Further studies are needed to establish whether these changes depend on factors like the type of treatment, species, strain, gender, time of treatment, and others. Full article
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19 pages, 534 KiB  
Review
The Past, Present, Future: Pathophysiology, Diagnosis, and Treatment of Human Skin Diseases
by Niki Ebrahimnejad, Duaa Jaafar and Heidi Goodarzi
Physiologia 2024, 4(1), 81-99; https://doi.org/10.3390/physiologia4010005 - 8 Feb 2024
Viewed by 3569
Abstract
When thinking of skin disease, cancer comes up almost immediately as an example. While the American Cancer Society lists 6 major cancer types, the National Institute of Arthritis and Musculoskeletal and Skin Diseases identifies 13 significant benign skin disorders, reflecting the diversity of [...] Read more.
When thinking of skin disease, cancer comes up almost immediately as an example. While the American Cancer Society lists 6 major cancer types, the National Institute of Arthritis and Musculoskeletal and Skin Diseases identifies 13 significant benign skin disorders, reflecting the diversity of skin conditions in dermatology. This topical review aims to provide an overview of the pathophysiology of these major skin cancers and disorders and to summarize conventional diagnostic methods and current treatment approaches. Full article
(This article belongs to the Special Issue Feature Papers in Human Physiology–2nd Edition)
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17 pages, 1831 KiB  
Article
Heat Stress but Not Capsaicin Application Alleviates the Hypertensive Response to Isometric Exercise
by Alexandros Sotiridis, Anastasios Makris, Maria D. Koskolou and Nickos D. Geladas
Physiologia 2024, 4(1), 64-80; https://doi.org/10.3390/physiologia4010004 - 23 Jan 2024
Viewed by 1135
Abstract
Heat stress and cutaneous capsaicin application act independently to reduce mean arterial blood pressure (MAP) at rest. The present study investigated whether a mixed intervention might alleviate to a greater extent the hypertensive response to isometric exercise. An end-exercise systolic blood pressure (SBP) [...] Read more.
Heat stress and cutaneous capsaicin application act independently to reduce mean arterial blood pressure (MAP) at rest. The present study investigated whether a mixed intervention might alleviate to a greater extent the hypertensive response to isometric exercise. An end-exercise systolic blood pressure (SBP) lower than 215 mmHg or higher than 220 mmHg was set for the inclusion in the group observed with typical (CON, n = 9) or hypertensive (HRE, n = 8) response to dynamic exercise, respectively. The participants performed four trials held in thermoneutral (TN:23 °C) or hot (HT:33 °C) conditions with capsaicin (CA:4.8 mg·patch−1) or placebo (PL) patches (12 × 18 cm2) applied to their two quadriceps, left pectoralis major and left scapula. The trials comprised: a 5 min baseline period preceding patch application, a 30 min rest period and a 5 min isometric handgrip exercise (20% maximal voluntary contraction, 10.1 ± 1.9 kg). Thermoregulatory and cardiovascular data were analyzed using mixed three-way ANOVA. End-resting MAP and pain sensation were higher in PL-TN (p = 0.008) and CA-HT (p = 0.012), respectively. End-exercise SBP tended to be higher in HRE individuals across environments (p = 0.10). Total peripheral resistance and MAP remained lower in HT across groups (p < 0.05). Despite the alleviating effect of the heat stressor, an augmented burning sensation-induced peripheral vasoconstriction might have blunted the pressure-lowering action of capsaicin. Full article
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10 pages, 962 KiB  
Article
Essential Fatty Acid Associated with Heart Rate Variability in Highly Trained Male Cross-Country Skiers: A Pilot Study
by Aleksandra Y. Lyudinina, Alexander L. Markov and Evgeny R. Bojko
Physiologia 2024, 4(1), 54-63; https://doi.org/10.3390/physiologia4010003 - 19 Jan 2024
Cited by 1 | Viewed by 1282
Abstract
Polyunsaturated fatty acid (PUFA) metabolites play important roles in the modulation of vascular tone, heart rate variability (HRV), and cardiovascular diseases. This study was undertaken to examine the relationship between HRV and the plasma levels of essential acids. Methods: Highly trained cross-country skiers [...] Read more.
Polyunsaturated fatty acid (PUFA) metabolites play important roles in the modulation of vascular tone, heart rate variability (HRV), and cardiovascular diseases. This study was undertaken to examine the relationship between HRV and the plasma levels of essential acids. Methods: Highly trained cross-country skiers participated in the study (n = 19). Time-domain and frequency-domain HRV analyses were performed. The plasma levels of fatty acids were determined using gas–liquid chromatography. Results: Plasma eicosapentaenoic acid and docosahexaenoic acid were found to be negatively correlated with resting heart rate (HR) (p = 0.026). The plasma levels of alpha-linolenic acid (ALA) were positively associated with the relative value of high-frequency power (rs = 0.465, p = 0.045) and negatively correlated with the sympathovagal balance ratio (rs = −0.493, p = 0.032) and the absolute and relative values of low-frequency power (rs = −0.490, p = 0.028). The plasma levels of arachidonic acid (ARA) were positively associated with the relative value of high-frequency power (rs = 0.59, p = 0.006) and negatively correlated with the sympathovagal balance ratio (rs = −0.54, p = 0.017) and the relative values of low-frequency power (rs = −0.52, p = 0.022). No correlation was found between n6/n3 and HRV parameters except for HR and pNN50. Conclusions: n-3 PUFAs and ARA play an important role in the autonomic regulation of heart rate in highly trained skiers. Athletes with substantial deficiencies in plasma ALA and excess levels of ARA had increased sympathetic and decreased parasympathetic activity. Full article
(This article belongs to the Special Issue Exercise Physiology and Biochemistry)
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11 pages, 271 KiB  
Article
Response of Olive Trees (Olea europaea L.) cv. Kalinioti to Nitrogen Fertilizer Application
by Dimitris Kotsias, Victor Kavvadias and Christos Pappas
Physiologia 2024, 4(1), 43-53; https://doi.org/10.3390/physiologia4010002 - 31 Dec 2023
Viewed by 2041
Abstract
Nitrogen is the most commonly managed mineral nutrient in olive groves because it is essential for plant growth. The precise management of N fertilization in olive cultivation is still not fully clarified, but it is essential for providing sustainable production. A nitrogen fertilizer [...] Read more.
Nitrogen is the most commonly managed mineral nutrient in olive groves because it is essential for plant growth. The precise management of N fertilization in olive cultivation is still not fully clarified, but it is essential for providing sustainable production. A nitrogen fertilizer experiment with olive trees (cv. Kalinioti) was carried out over a six-year period. Seven levels of nitrogen fertilizer given as ammonium nitrate (control, 1, 2, 3, 4, 5, and 6 kg/tree) were annually applied in order to determine the effect of nitrogen on vegetative growth, fruit set, fruit weight, yield, maturation index, and leaf N, P, and K concentrations. The results indicate that, under these conditions, application of up to 4 kg NH4NO3/tree significantly increased yield to 62.5 kg/tree compared to the control (37.09 kg/tree). The positive effect was attributed to the initial and final fruit set increases (7.63 and 3.73%, respectively at 4 kg NH4NO3/tree). However, the weight of 100 olives (W100 = 331 g) at 4 kg NH4NO3/tree obtained during harvest was considerably lower compared to the control (W100 = 384 g). Higher nitrogen rates decreased yield while increasing overall shoot growth. Nitrogen fertilization did not significantly influence the oil content of olive fruit. Fruit weight, maturation index, and concentration of oil reached maximum levels in the beginning of December, indicating a suitable start to olive harvesting. The concentration of N in olive leaves increased from 1.23% to 2.38% as fertilizer levels increased from 0 to 6 kg NH4NO3. Maximum yield was achieved at a level of 6 kg NH4NO3/tree, which corresponded to 2.01% N in leaves. The results suggest that application of 3 kg NH4NO3/tree can be recommended for table olive production, due to the fact that fruit weight was not decreased, while fertilization with 4 kg NH4NO3/tree was suitable for oil olives. Full article
42 pages, 4905 KiB  
Systematic Review
Advances in Modeling and Interpretability of Deep Neural Sleep Staging: A Systematic Review
by Reza Soleimani, Jeffrey Barahona, Yuhan Chen, Alper Bozkurt, Michael Daniele, Vladimir Pozdin and Edgar Lobaton
Physiologia 2024, 4(1), 1-42; https://doi.org/10.3390/physiologia4010001 - 20 Dec 2023
Cited by 1 | Viewed by 2120
Abstract
Sleep staging has a very important role in diagnosing patients with sleep disorders. In general, this task is very time-consuming for physicians to perform. Deep learning shows great potential to automate this process and remove physician bias from decision making. In this study, [...] Read more.
Sleep staging has a very important role in diagnosing patients with sleep disorders. In general, this task is very time-consuming for physicians to perform. Deep learning shows great potential to automate this process and remove physician bias from decision making. In this study, we aim to identify recent trends on performance improvement and the causes for these trends. Recent papers on sleep stage classification and interpretability are investigated to explore different modeling and data manipulation techniques, their efficiency, and recent advances. We identify an improvement in performance up to 12% on standard datasets over the last 5 years. The improvements in performance do not appear to be necessarily correlated to the size of the models, but instead seem to be caused by incorporating new architectural components, such as the use of transformers and contrastive learning. Full article
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