New Bayesian Posterior Approaches for Cytogenetic Partial Body Irradiation Inference

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript idea is clear and well-written and represented, however it might be closer to the statistical nature than to radiation although the main problem is related to radiation.  Some results (about one or two lines) can be added to the abstract. for the methodology, two donors might not be enough to represent groups. Figures 1 and 3 can be combined together, while colors of figure 4 can be more visible if more bright grades were used. impact of the presented methods on the evaluated radiation doses is not clear and associated uncertainties are not discussed.

Author Response

Dear Reviewer,

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The Authors.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

My suggestions/ observations are as under

1. Abstract missing the conclusion remark of study.
2. Abbreviations missing Qdr????Need to elaborate.
3. difficult to understand sentence Page 7 line 159.....connecting with C?????

Author Response

Dear Reviewer,

Please, find attached our response.

The Authors.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The presented manuscript entitled "New Bayesian Posterior Approaches for Cytogenetic Partial Body Irradiation Inference" is very well written and accurate. I find it very useful in the field of biodosimetry. All calculations are correct and cover recent knowledge. I have only three minor comments:

1) the Authors cited one quite old review paper (from 2014) on other bayesian methods. I recommend to add a sub-chapter and/or table with recent very (!) short review of all bayesian methods in biodosimetry, including those published after 2014. 

2) Laplace approximation - some additional information on the lack of precision should be added. Especially, under what conditions this lack of precision is significant.

3) Bayesian methods, as a subjective approach, can have potential disadvantages. Some broader discussion on this issue should be added; for example, some comparison between your method(s) and classical ones in the analogical partial body irradiation scheme.

Author Response

Dear Reviewer,

Please, find attached our response.

The Authors.

Author Response File: Author Response.pdf