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Transplantology, Volume 2, Issue 3

September 2021 - 13 articles

Cover Story: Coronavirus disease 2019 (COVID-19) has an increased incidence and risk of severe infection among immunocompromised patients. Recently, it has been suggested that COVID-19 cycle threshold values (Ct) obtained on polymerase chain reaction (PCR) tests may serve as a marker of disease severity with lower values (i.e., higher viral load) being associated with higher mortality. In this issue, Winstead and colleagues evaluate the impact of remdesivir use on the time to a negative COVID-19 PCR as well as the degree of change between two Ct’s based on treatment with remdesivir after kidney transplantation. View this paper.
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Articles (13)

  • Review
  • Open Access
5 Citations
4,820 Views
17 Pages

Persufflation—Current State of Play

  • Aaron John Buhagiar,
  • Leo Freitas and
  • William E. Scott

With the ever-increasing disparity between the number of patients waiting for organ transplants and the number organs available, some patients are unable to receive life-saving transplantation in time. The present, widely-used form of preservation is...

  • Review
  • Open Access
7 Citations
6,636 Views
15 Pages

Donor-Derived Cell-Free DNA to Diagnose Graft Rejection Post-Transplant: Past, Present and Future

  • Naveen Kumar,
  • Rashmi Rana,
  • Devender Singh Rana,
  • Anurag Gupta and
  • Mohinder Pal Sachdeva

Donor-derived cell-free DNA (dd-cfDNA) is a non-invasive biomarker that is more sensitive and specific towards diagnosing any graft injury or rejection. Due to its applicability over all transplanted organs irrespective of age, sex, race, ethnicity,...

  • Review
  • Open Access
8 Citations
9,269 Views
13 Pages

Epitope-Level Matching—A Review of the Novel Concept of Eplets in Transplant Histocompatibility

  • André Renaldo,
  • Adriel Roa-Bautista,
  • Elena González-López,
  • Marcos López-Hoyos and
  • David San Segundo

The development of de novo donor-specific antibodies is related to the poor matching of the human leukocyte antigen (HLA) between donor and recipient, which leads to dismal clinical outcomes and graft loss. However, new approaches that stratify the r...

  • Review
  • Open Access
5 Citations
16,313 Views
21 Pages

Kidney Failure after Liver Transplantation

  • Eloïse Colliou,
  • Arnaud Del Bello,
  • David Milongo,
  • Fabrice Muscari,
  • Marion Vallet,
  • Ivan Tack and
  • Nassim Kamar

One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liv...

  • Feature Paper
  • Article
  • Open Access
2 Citations
4,133 Views
11 Pages

The Effects of 6-Chromanol SUL-138 during Hypothermic Machine Perfusion on Porcine Deceased Donor Kidneys

  • L. Annick van Furth,
  • Leonie H. Venema,
  • Koen D. W. Hendriks,
  • Pieter C. Vogelaar,
  • Guido Krenning and
  • Henri G. D. Leuvenink

Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for kidney transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting tar...

  • Brief Report
  • Open Access
3 Citations
3,685 Views
3 Pages

Effect of Remdesivir on COVID-19 PCR Positivity and Cycle Threshold in Kidney Transplant Recipients

  • Ryan J. Winstead,
  • Johanna Christensen,
  • Sara Sterling,
  • Megan Morales,
  • Dhiren Kumar,
  • Alexandra Bryson and
  • Gaurav Gupta

Information regarding Coronavirus disease 2019 in the transplant population is lacking. Recently it has been suggested that cycle threshold values obtained on polymerase chain reaction tests may serve as a marker of disease severity with lower values...

  • Communication
  • Open Access
6 Citations
4,839 Views
8 Pages

COVID-19 Severity and Mortality in Solid Organ Transplantation: Differences between Liver, Heart, and Kidney Recipients

  • Ricardo Wesley Alberca,
  • Gabriela Gama Freire Alberca,
  • Lucas Chaves Netto,
  • Raquel Leão Orfali,
  • Sarah Cristina Gozzi-Silva,
  • Alberto José da Silva Duarte,
  • Valeria Aoki,
  • Maria Notomi Sato and
  • Gil Benard

The infection by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can generate a wide spectrum of clinical manifestations ranging from asymptomatic to severe respiratory and systemic disease with coagulation disorder named coronavirus...

  • Feature Paper
  • Review
  • Open Access
3 Citations
16,591 Views
14 Pages

Mental Health and Well-Being of Solid Organ Transplant Donors. The Forgotten Sacrifices

  • Xin-Hui Pan,
  • Jonathan Zhi Kai Toh,
  • Cheng Han Ng,
  • Phoebe Wen Lin Tay,
  • Neng Wei Wong,
  • Alfred Wei Chieh Kow,
  • Anantharaman Vathsala,
  • Eunice Xiang-Xuan Tan,
  • Mark Dhinesh Muthiah and
  • Wen Hui Lim

In light of a global organ shortage, living donor transplantation has become increasingly relevant as an alternative to deceased donor transplantation. While current research has revolved around the medical aspects of transplantation, there remains a...

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Transplantology - ISSN 2673-3943